2024-03-28T11:58:21Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/69312022-07-28T08:04:05Zcom_20.500.12105_2060com_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_2061
00925njm 22002777a 4500
dc
Casado, Concepcion
author
Colombo, Sara
author
Rauch, Andri
author
Martínez, Raquel
author
Günthard, Huldrych F
author
Garcia, Soledad
author
Rodríguez, Carmen
author
Del Romero, Jorge
author
Telenti, Amalio
author
Lopez-Galindez, Luis Cecilio
author
2010-06-11
BACKGROUND: Various patterns of HIV-1 disease progression are described in clinical practice and in research. There is a need to assess the specificity of commonly used definitions of long term non-progressor (LTNP) elite controllers (LTNP-EC), viremic controllers (LTNP-VC), and viremic non controllers (LTNP-NC), as well as of chronic progressors (P) and rapid progressors (RP). METHODOLOGY AND PRINCIPAL FINDINGS: We re-evaluated the HIV-1 clinical definitions, summarized in Table 1, using the information provided by a selected number of host genetic markers and viral factors. There is a continuous decrease of protective factors and an accumulation of risk factors from LTNP-EC to RP. Statistical differences in frequency of protective HLA-B alleles (p-0.01), HLA-C rs9264942 (p-0.06), and protective CCR5/CCR2 haplotypes (p-0.02) across groups, and the presence of viruses with an ancestral genotype in the "viral dating" (i.e., nucleotide sequences with low viral divergence from the most recent common ancestor) support the differences among principal clinical groups of HIV-1 infected individuals. CONCLUSIONS: A combination of host genetic and viral factors supports current clinical definitions that discriminate among patterns of HIV-1 progression. The study also emphasizes the need to apply a standardized and accepted set of clinical definitions for the purpose of disease stratification and research.
PLoS One. 2010 Jun 11;5(6):e11079.
1932-6203
http://hdl.handle.net/20.500.12105/6931
20552027
10.1371/journal.pone.0011079
1932-6203
PloS one
Host and viral genetic correlates of clinical definitions of HIV-1 disease progression