2024-03-29T11:17:48Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/68182023-10-05T14:25:14Zcom_20.500.12105_2053com_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_2054
00925njm 22002777a 4500
dc
Lope Carvajal, Virginia
author
Fernandez de Larrea-Baz, Nerea
author
Perez-Gomez, Beatriz
author
Martín, Vicente
author
Moreno, Victor
author
Costas, Laura
author
Longo, Federico
author
Jimenez-Moleon, Jose J.
author
Llorca, Javier
author
Ascunce, Nieves
author
Peiró-Pérez, Rosana
author
Altzibar, Jone M
author
Tardón, Adonina
author
Alguacil, Juan
author
Navarro, Carmen
author
Sierra, Maria Angeles
author
Vega, Ana Belén
author
Villafañe, Amaya
author
Castaño-Vinyals, Gemma
author
Kogevinas, Manolis
author
Pollan-Santamaria, Marina
author
Aragones, Nuria
author
2016-10-24
BACKGROUND: Sex hormones play a role in gastric cancer and colorectal cancer etiology, however, epidemiological evidence is inconsistent. This study examines the influence of menstrual and reproductive factors over the risk of both tumors. METHODS: In this case-control study 128 women with gastric cancer and 1293 controls, as well as 562 female and colorectal cancer cases and 1605 controls were recruited in 9 and 11 Spanish provinces, respectively. Population controls were frequency matched to cases by age and province. Demographic and reproductive data were directly surveyed by trained staff. The association with gastric, colon and rectal cancer was assessed using logistic and multinomial mixed regression models. RESULTS: Our results show an inverse association of age at first birth with gastric cancer risk (five-year trend: OR = 0.69; p-value = 0.006). Ever users of hormonal contraception presented a decreased risk of gastric (OR = 0.42; 95%CI = 0.26-0.69), colon (OR = 0.64; 95%CI = 0.48-0.86) and rectal cancer (OR = 0.61; 95%CI = 0.43-0.88). Postmenopausal women who used hormone replacement therapy showed a decreased risk of colon and rectal tumors. A significant interaction of educational level with parity and months of first child lactation was also observed. CONCLUSION: These findings suggest a protective role of exogenous hormones in gastric and colorectal cancer risk. The role of endogenous hormones remains unclear.
PLoS One. 2016 Oct 24;11(10):e0164620
1932-6203
http://hdl.handle.net/20.500.12105/6818
27776142
10.1371/journal.pone.0164620
1932-6203
PloS one
Menstrual and Reproductive Factors and Risk of Gastric and Colorectal Cancer in Spain