2024-03-28T14:22:17Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/67782023-10-10T08:15:44Zcom_20.500.12105_2088com_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_2074col_20.500.12105_2089col_20.500.12105_2075
00925njm 22002777a 4500
dc
Ochando, Jordi
author
Berzosa, Pedro
author
Lucio, Aida de
author
Descalzo, Miguel Angel
author
Bobuakasi, Leonardo
author
Nzambo, Sisinio
author
Ondo, Melchor
author
Buatiche, Jesus N
author
Nseng, Gloria
author
Benito, Agustin
author
2007-10-25
BACKGROUND: Malaria transmission in Equatorial Guinea and its space-time variability has been widely studied, but there is not much information about the transmission of malaria on the small island of Annobon. In 2004, two transversal studies were carried out to establish the malaria transmission pattern on Annobon and analyse the circulating Plasmodium falciparum allelic forms. METHODS: A blood sample was taken from the selected children in order to determine Plasmodium infection by microscopical examination and by semi-nested multiplex PCR. The diversity of P. falciparum circulating alleles was studied on the basis of the genes encoding for the merozoite surface proteins, MSP-1 and MSP-2 of P. falciparum. RESULTS: The crude parasite rate was 17% during the dry season and 60% during the rainy season. The percentage of children sleeping under a bed net was over 80% in the two surveys. During the rainy season, 33.3% of the children surveyed were anaemic at the time of the study. No association was found between the crude parasite rate, the use of bed nets and gender, and anaemia. However, children between five and nine years of age were five times less at risk of being anaemic than those aged less than one year. A total of 28 populations of the three allelic families of the msp-1 gene were identified and 39 of the msp-2 gene. The variability of circulating allelic populations is significantly higher in the rainy than in the dry season, although the multiplicity of infections is similar in both, 2.2 and 1.9 respectively. CONCLUSION: Based on the high degree of geographical isolation of the Annobon population and the apparent marked seasonality of the transmission, it is feasible to believe that malaria can be well controlled from this small African island.
Malar J. 2007; 6: 141.
1475-2875
http://hdl.handle.net/20.500.12105/6778
17961248
10.1186/1475-2875-6-141
1475-2875
Malaria journal
Transmission of malaria and genotypic variability of Plasmodium falciparum on the island of Annobon (Equatorial Guinea)