2024-03-28T10:04:59Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/65322023-10-06T07:39:41Zcom_20.500.12105_2145com_20.500.12105_2051com_20.500.12105_2144col_20.500.12105_2146
00925njm 22002777a 4500
dc
Rodriguez-Galan, Ana
author
Fernandez-Messina, Lola
author
Sanchez-Madrid, Francisco
author
2018
MiRNA targeting of key immunoregulatory molecules fine-tunes the immune response. This mechanism boosts or dampens immune functions to preserve homeostasis while supporting the full development of effector functions. MiRNA expression changes during T cell activation, highlighting that their function is constrained by a specific spatiotemporal frame related to the signals that induce T cell-based effector functions. Here, we update the state of the art regarding the miRNAs that are differentially expressed during T cell stimulation. We also revisit the existing data on miRNA function in T cell activation, with a special focus on the modulation of the most relevant immunoregulatory molecules.
Front Immunol. 2018; 9:2148
1664-3224
http://hdl.handle.net/20.500.12105/6532
30319616
10.3389/fimmu.2018.02148
Frontiers in Immunology
T cell activation
MicroRNAs (miRNAs)
Immunoregulatory molecules
miRNA signature
CD4
CD8
T lymphocyte
EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
SYSTEMIC-LUPUS-ERYTHEMATOSUS
MICRORNA-MEDIATED REGULATION
IMMUNE-RESPONSE
TGF-BETA
MULTIPLE-SCLEROSIS
RNA-INTERFERENCE
GENE-EXPRESSION
DOWN-REGULATION
CYTOKINE PRODUCTION
Control of Immunoregulatory Molecules by miRNAs in T Cell Activation