2024-03-28T17:53:58Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/65222022-09-05T12:03:11Zcom_20.500.12105_2145com_20.500.12105_2051com_20.500.12105_2144col_20.500.12105_2146
00925njm 22002777a 4500
dc
Casasnovas, Jose A.
author
Alcaide, Victor
author
Civeira, Fernando
author
Guallar, Eliseo
author
Ibáñez, Borja
author
Jimenez-Borreguero, Luis J.
author
Laclaustra, Martin
author
Leon, Montserrat
author
Peñalvo, Jose L
author
Ordovas, Jose M
author
Pocovi, Miguel
author
Sanz, Gines
author
Fuster, Valentin
author
2012
Background: Spain, a Mediterranean country with relatively low rates of coronary heart disease, has a high prevalence of traditional cardiovascular risk factors and is experiencing a severe epidemic of overweight/obesity. We designed the Aragon Workers' Health Study (AWHS) to characterize the factors associated with metabolic abnormalities and subclinical atherosclerosis in a middle aged population in Spain free of clinical cardiovascular disease. The objective of this paper is to describe the study design, aims and baseline characteristics of participants in the AWHS. Methods/Design: Longitudinal cohort study based on the annual health exams of 5,400 workers of a car assembly plant in Figueruelas (Zaragoza, Spain). Study participants were recruited during a standardized clinical exam in 2009-2010 (participation rate 95.6\%). Study participants will undergo annual clinical exams and laboratory assays, and baseline and triennial collection of biological materials for biobanking and cardiovascular imaging exams (carotid, femoral and abdominal ultrasonography, coronary calcium score, and ankle-arm blood pressure index). Participants will be followed-up for 10 years. Results: The average (SD) age, body mass index, and waist circumference were 49.3 (8.7) years, 27.7 (3.6) kg/m(2) and 97.2 (9.9) cm, respectively, among males (N = 5,048), and 40.8 (11.6) years, 24.4 (3.8) kg/m(2), and 81.9 (9.9) cm, among females (N = 351). The prevalence of overweight, obesity, current smoking, hypertension, hypercholesterolemia, and diabetes were 55.0, 23.1, 37.1, 40.3, 75.0, and 7.4\%, respectively, among males, and 23.7, 8.3, 45.0, 12.1, 59.5, and 0.6\%, respectively, among females. In the initial 587 study participants who completed all imaging exams (94.5\% male), the prevalence of carotid plaque, femoral plaque, coronary calcium score >1 to 100, and coronary calcium score >100 was 30.3, 56.9, 27.0, and 8.8\%, respectively. 67.7\% of study participants had at least one plaque in the carotid or femoral arteries. Discussion: Baseline data from the AWHS show a high prevalence of cardiovascular risk factors and of sublinical atherosclerosis. Follow-up of this cohort will allow the assessment of subclinical atherosclerosis progression and the link of disease progression to traditional and emergent risk factors.
BMC Cardiovasc Disord. 2012; 12(1):45
1471-2261
http://hdl.handle.net/20.500.12105/6522
22712826
10.1186/1471-2261-12-45
BMC CARDIOVASCULAR DISORDERS
CARDIOVASCULAR RISK-FACTORS
INTIMA-MEDIA THICKNESS
MONICA PROJECT POPULATIONS
SPANISH WORKING POPULATION
CORONARY-HEART-DISEASE
CONSENSUS STATEMENT
AMERICAN SOCIETY
EVENT RATES
TASK-FORCE
PREVALENCE
Aragon workers' health study - design and cohort description