2024-03-19T05:03:06Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/65112023-10-11T08:49:35Zcom_20.500.12105_2174com_20.500.12105_2051com_20.500.12105_2173col_20.500.12105_2175
00925njm 22002777a 4500
dc
Klein, Alison P
author
Wolpin, Brian M
author
Risch, Harvey A
author
Stolzenberg-Solomon, Rachael Z
author
Mocci, Evelina
author
Zhang, Mingfeng
author
Canzian, Federico
author
Childs, Erica J
author
Hoskins, Jason W
author
Jermusyk, Ashley
author
Zhong, Jun
author
Wentzensen, Nicolas
author
Albanes, Demetrius
author
White, Emily
author
Yu, Herbert
author
Yu, Kai
author
Zheng, Wei
author
Kraft, Peter
author
Li, Donghui
author
Obazee, Ofure
author
Petersen, Gloria M
author
Brais, Lauren
author
Amundadottir, Laufey T
author
Andreotti, Gabriella
author
Arslan, Alan A
author
Buring, Julie
author
Babic, Ana
author
Bamlet, William R
author
Beane-Freeman, Laura
author
Chaffee, Kari G
author
Berndt, Sonja I
author
Blackford, Amanda
author
Chung, Charles C
author
Borges, Michael
author
Borgida, Ayelet
author
Bracci, Paige M
author
Brennan, Paul
author
Brenner, Hermann
author
Bueno-de-Mesquita, Bas
author
Campa, Daniele
author
Capurso, Gabriele
author
Cavestro, Giulia Martina
author
Cleary, Sean
author
Cotterchio, Michelle
author
Goodman, Gary E
author
Dijk, Frederike
author
Duell, Eric J
author
Foretova, Lenka
author
Hartge, Patricia
author
Fuchs, Charles
author
Funel, Niccola
author
Gallinger, Steven
author
Herman, Joseph
author
M Gaziano, J Michael
author
Gazouli, Maria
author
Holcatova, Ivana
author
Giles, Graham G
author
Giovannucci, Edward
author
Goggins, Michael
author
Goodman, Phyllis J
author
Hackert, Thilo
author
Haiman, Christopher
author
Hasan, Manal
author
Hegyi, Peter
author
Helzlsouer, Kathy J
author
Holly, Elizabeth A
author
Hoover, Robert
author
Kurtz, Robert J
author
Hung, Rayjean J
author
Jacobs, Eric J
author
Jamroziak, Krzysztof
author
Lee, I-Min
author
Janout, Vladimir
author
Kaaks, Rudolf
author
Khaw, Kay-Tee
author
Mambrini, Andrea
author
Klein, Eric A
author
Kogevinas, Manolis
author
Mannisto, Satu
author
Kooperberg, Charles
author
Kulke, Matthew H
author
Kupcinskas, Juozas
author
Laheru, Daniel
author
Landi, Stefano
author
Lawlor, Rita T
author
LeMarchand, Loic
author
Lu, Lingeng
author
Malats, Núria
author
Milne, Roger L
author
Mohelníková-Duchoňová, Beatrice
author
Rothman, Nathaniel
author
Neale, Rachel E
author
Neoptolemos, John P
author
Oberg, Ann L
author
Shu, Xiao-Ou
author
Olson, Sara H
author
Orlow, Irene
author
Pasquali, Claudio
author
Sund, Malin
author
Patel, Alpa V
author
Peters, Ulrike
author
Talar-Wojnarowska, Renata
author
Pezzilli, Raffaele
author
Porta, Miquel
author
Real Arribas, Francisco
author
Scelo, Ghislaine
author
Sesso, Howard D
author
Severi, Gianluca
author
Silverman, Debra
author
Smith, Jill P
author
Soucek, Pavel
author
Tavano, Francesca
author
Thornquist, Mark D
author
Zeleniuch-Jacquotte, Anne
author
Tobias, Geoffrey S
author
Van Den Eeden, Stephen K
author
Vashist, Yogesh
author
Chanock, Stephen
author
Visvanathan, Kala
author
Vodicka, Pavel
author
Wactawski-Wende, Jean
author
Chen, Fei
author
Wang, Zhaoming
author
2018-02-08
In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to date, including 9040 patients and 12,496 controls of European ancestry from the Pancreatic Cancer Cohort Consortium (PanScan) and the Pancreatic Cancer Case-Control Consortium (PanC4). Here, we find significant evidence of a novel association at rs78417682 (7p12/TNS3, P = 4.35 × 10-8). Replication of 10 promising signals in up to 2737 patients and 4752 controls from the PANcreatic Disease ReseArch (PANDoRA) consortium yields new genome-wide significant loci: rs13303010 at 1p36.33 (NOC2L, P = 8.36 × 10-14), rs2941471 at 8q21.11 (HNF4G, P = 6.60 × 10-10), rs4795218 at 17q12 (HNF1B, P = 1.32 × 10-8), and rs1517037 at 18q21.32 (GRP, P = 3.28 × 10-8). rs78417682 is not statistically significantly associated with pancreatic cancer in PANDoRA. Expression quantitative trait locus analysis in three independent pancreatic data sets provides molecular support of NOC2L as a pancreatic cancer susceptibility gene.
Nat Commun. 2018; 9(1): 556.
2041-1723
http://hdl.handle.net/20.500.12105/6511
29422604
10.1038/s41467-018-02942-5
2041-1723
Nature communications
BODY-MASS INDEX
ASSOCIATION ANALYSES
GENE-EXPRESSION
TRANSCRIPTION FACTORS
RISK
IMPUTATION
DISEASE
ADENOCARCINOMA
Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer