2024-03-28T14:52:24Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/64462023-09-28T07:22:20Zcom_20.500.12105_2088com_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_2089
00925njm 22002777a 4500
dc
Lorenz, Matthias W
author
Gao, Lu
author
Ziegelbauer, Kathrin
author
Norata, Giuseppe Danilo
author
Empana, Jean Philippe
author
Schmidtmann, Irene
author
Lin, Hung-Ju
author
McLachlan, Stela
author
Bokemark, Lena
author
Ronkainen, Kimmo
author
Amato, Mauro
author
Schminke, Ulf
author
Srinivasan, Sathanur R
author
Lind, Lars
author
Okazaki, Shuhei
author
Stehouwer, Coen D A
author
Willeit, Peter
author
Polak, Joseph F
author
Steinmetz, Helmuth
author
Sander, Dirk
author
Poppert, Holger
author
Desvarieux, Moise
author
Ikram, M Arfan
author
Johnsen, Stein Harald
author
Staub, Daniel
author
Sirtori, Cesare R
author
Iglseder, Bernhard
author
Beloqui, Oscar
author
Engström, Gunnar
author
Friera, Alfonso
author
Rozza, Francesco
author
Xie, Wuxiang
author
Parraga, Grace
author
Grigore, Liliana
author
Plichart, Matthieu
author
Blankenberg, Stefan
author
Su, Ta-Chen
author
Schmidt, Caroline
author
Tuomainen, Tomi-Pekka
author
Veglia, Fabrizio
author
Völzke, Henry
author
Nijpels, Giel
author
Willeit, Johann
author
Sacco, Ralph L
author
Franco, Oscar H
author
Uthoff, Heiko
author
Hedblad, Bo
author
Suarez, Carmen
author
Izzo, Raffaele
author
Zhao, Dong
author
Wannarong, Thapat
author
Catapano, Alberico
author
Ducimetiere, Pierre
author
Espinola-Klein, Christine
author
Chien, Kuo-Liong
author
Price, Jackie F
author
Bergström, Göran
author
Kauhanen, Jussi
author
Tremoli, Elena
author
Dörr, Marcus
author
Berenson, Gerald
author
Kitagawa, Kazuo
author
Dekker, Jacqueline M
author
Kiechl, Stefan
author
Sitzer, Matthias
author
Bickel, Horst
author
Rundek, Tatjana
author
Hofman, Albert
author
Mathiesen, Ellisiv B
author
Castelnuovo, Samuela
author
Landecho, Manuel F
author
Rosvall, Maria
author
Gabriel-Sanchez, Rafael
author
de Luca, Nicola
author
Liu, Jing
author
Baldassarre, Damiano
author
Kavousi, Maryam
author
de Groot, Eric
author
Bots, Michiel L
author
Yanez, David N
author
Thompson, Simon G
author
2018
AIMS: Carotid intima media thickness (CIMT) predicts cardiovascular (CVD) events, but the predictive value of CIMT change is debated. We assessed the relation between CIMT change and events in individuals at high cardiovascular risk. METHODS AND RESULTS: From 31 cohorts with two CIMT scans (total n = 89070) on average 3.6 years apart and clinical follow-up, subcohorts were drawn: (A) individuals with at least 3 cardiovascular risk factors without previous CVD events, (B) individuals with carotid plaques without previous CVD events, and (C) individuals with previous CVD events. Cox regression models were fit to estimate the hazard ratio (HR) of the combined endpoint (myocardial infarction, stroke or vascular death) per standard deviation (SD) of CIMT change, adjusted for CVD risk factors. These HRs were pooled across studies. In groups A, B and C we observed 3483, 2845 and 1165 endpoint events, respectively. Average common CIMT was 0.79mm (SD 0.16mm), and annual common CIMT change was 0.01mm (SD 0.07mm), both in group A. The pooled HR per SD of annual common CIMT change (0.02 to 0.43mm) was 0.99 (95% confidence interval: 0.95-1.02) in group A, 0.98 (0.93-1.04) in group B, and 0.95 (0.89-1.04) in group C. The HR per SD of common CIMT (average of the first and the second CIMT scan, 0.09 to 0.75mm) was 1.15 (1.07-1.23) in group A, 1.13 (1.05-1.22) in group B, and 1.12 (1.05-1.20) in group C. CONCLUSIONS: We confirm that common CIMT is associated with future CVD events in individuals at high risk. CIMT change does not relate to future event risk in high-risk individuals.
PLoS One. 2018 Apr 12;13(4):e0191172
1932-6203
http://hdl.handle.net/20.500.12105/6446
29649236
10.1371/journal.pone.0191172
1932-6203
PloS one
Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk - Results from the PROG-IMT collaboration