2024-03-28T14:07:34Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/55212022-06-08T09:40:01Zcom_20.500.12105_2145com_20.500.12105_2051com_20.500.12105_2144col_20.500.12105_2146
00925njm 22002777a 4500
dc
Yanez-Mo, Maria
author
Siljander, Pia R. -M.
author
Andreu, Zoraida
author
Zavec, Apolonija Bedina
author
Borras, Francesc E.
author
Buzas, Edit I.
author
Buzas, Krisztina
author
Casal, Enriqueta
author
Cappello, Francesco
author
Carvalho, Joana
author
Colas, Eva
author
Cordeiro-da Silva, Anabela
author
Fais, Stefano
author
Falcon-Perez, Juan Manuel
author
Ghobrial, Irene M.
author
Giebel, Bernd
author
Gimona, Mario
author
Graner, Michael
author
Gursel, Ihsan
author
Gursel, Mayda
author
Heegaard, Niels H. H.
author
Hendrix, An
author
Kierulf, Peter
author
Kokubun, Katsutoshi
author
Kosanovic, Maja
author
Kralj-Iglic, Veronika
author
Kraemer-Albers, Eva-Maria
author
Laitinen, Saara
author
Lasser, Cecilia
author
Lener, Thomas
author
Ligeti, Erzsebet
author
Line, Aija
author
Lipps, Georg
author
Llorente, Alicia
author
Lotvall, Jan
author
Mancek-Keber, Mateja
author
Marcilla, Antonio
author
Mittelbrunn, Maria
author
Nazarenko, Irina
author
Nolte-t' Hoen, Esther N. M.
author
Nyman, Tuula A.
author
O'Driscoll, Lorraine
author
Olivan, Mireia
author
Oliveira, Carla
author
Pallinger, Eva
author
del Portillo, Hernando A.
author
Reventos, Jaume
author
Rigau, Marina
author
Rohde, Eva
author
Sammar, Marei
author
Sanchez-Madrid, Francisco
author
Santarem, N.
author
Schallmoser, Katharina
author
Ostenfeld, Marie Stampe
author
Stoorvogel, Willem
author
Stukelj, Roman
author
Van der Grein, Susanne G.
author
Helena Vasconcelos, M.
author
Wauben, Marca H. M.
author
De Wever, Olivier
author
2015
In the past decade, extracellular vesicles (EVs) have been recognized as potent vehicles of intercellular communication, both in prokaryotes and eukaryotes. This is due to their capacity to transfer proteins, lipids and nucleic acids, thereby influencing various physiological and pathological functions of both recipient and parent cells. While intensive investigation has targeted the role of EVs in different pathological processes, for example, in cancer and autoimmune diseases, the EV-mediated maintenance of homeostasis and the regulation of physiological functions have remained less explored. Here, we provide a comprehensive overview of the current understanding of the physiological roles of EVs, which has been written by crowd-sourcing, drawing on the unique EV expertise of academia-based scientists, clinicians and industry based in 27 European countries, the United States and Australia. This review is intended to be of relevance to both researchers already working on EV biology and to newcomers who will encounter this universal cell biological system. Therefore, here we address the molecular contents and functions of EVs in various tissues and body fluids from cell systems to organs. We also review the physiological mechanisms of EVs in bacteria, lower eukaryotes and plants to highlight the functional uniformity of this emerging communication system.
J Extracell Vesicles. 2015; 4:27066
2001-3078
http://hdl.handle.net/20.500.12105/5521
25979354
10.3402/jev.v4.27066
Journal of Extracellular Vesicles
extracellular vesicle
microvesicle
microparticle
exosome
physiology
prokaryote
eukaryote
OUTER-MEMBRANE VESICLES
CELL-DERIVED EXOSOMES
MESENCHYMAL STEM-CELLS
INTESTINAL EPITHELIAL-CELLS
MATURE DENDRITIC CELLS
SYNCYTIOTROPHOBLAST MICROVILLOUS MEMBRANES
IMMUNE-MODULATORY FEATURES
PLANT-MICROBE INTERACTIONS
FACTOR PATHWAY INHIBITOR
HUMAN ENDOTHELIAL-CELLS
Biological properties of extracellular vesicles and their physiological functions