2024-03-29T13:28:59Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/51652023-10-10T07:29:25Zcom_20.500.12105_2145com_20.500.12105_2051com_20.500.12105_2144col_20.500.12105_2146
00925njm 22002777a 4500
dc
Sanchez-Aguilera, Abel
author
Mendez-Ferrer, Simon
author
2017
Research in the last decade has shown that hematopoietic stem cells (HSCs) interact with and are modulated by a complex multicellular microenvironment in the bone marrow, which includes both the HSC progeny and multiple non-hematopoietic cell types. Intense work is gradually throwing light on the composition of the HSC niche and the molecular cues exchanged between its components, which has implications for HSC production, maintenance and expansion. In addition, it has become apparent that bidirectional interactions between leukemic cells and their niche play a previously unrecognized role in the initiation and development of hematological malignancies. Consequently, targeting of the malignant niche holds considerable promise for more specific antileukemic therapies. Here we summarize the latest insights into HSC niche biology and recent work showing multiple connections between hematological malignancy and alterations in the bone marrow microenvironment.
Cell Mol Life Sci. 2017; 74(4):579-590
1420-682X
http://hdl.handle.net/20.500.12105/5165
27436341
10.1007/s00018-016-2306-y
1420-9071
Cellular and Molecular Life Sciences
Hematopoietic stem cell
Stem cell niche
Bone marrow microenvironment
Leukemia
Leukemia stem cell
BONE-MARROW NICHE
CHRONIC MYELOGENOUS LEUKEMIA
MESENCHYMAL STROMAL CELLS
ACUTE MYELOID-LEUKEMIA
IN-VIVO
PROGENITOR CELLS
ENDOTHELIAL NICHES
SELF-RENEWAL
MOUSE MODEL
MICROENVIRONMENT
The hematopoietic stem-cell niche in health and leukemia