2024-03-29T10:29:02Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/152392023-04-20T14:30:57Zcom_20.500.12105_2067com_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_2068
00925njm 22002777a 4500
dc
Tarazona, Jose
author
Cattaneo, Irene
author
Niemann, Lars
author
Pedraza-Diaz, Susana
author
González-Caballero, MCarmen
author
De Alba-González, Mercedes
author
Cañas Portilla, Ana Isabel
author
Domínguez-Morueco, Noelia
author
Esteban-Lopez, Marta
author
Castaño, Argelia
author
Borges, Teresa
author
Katsonouri, Andromachi
author
Makris, Konstantinos C
author
Ottenbros, Ilse
author
Mol, Hans
author
De Decker, Annelies
author
Morrens, Bert
author
Berman, Tamar
author
Barnett-Itzhaki, Zohar
author
Probst-Hensch, Nicole
author
Fuhrimann, Samuel
author
Tratnik, Janja Snoj
author
Horvat, Milena
author
Rambaud, Loic
author
Riou, Margaux
author
Schoeters, Greet
author
Govarts, Eva
author
Kolossa-Gehring, Marike
author
Weber, Till
author
Apel, Petra
author
Namorado, Sonia
author
Santonen, Tiina
author
2022-08-04
Pyrethroids are a major insecticide class, suitable for biomonitoring in humans. Due to similarities in structure and metabolic pathways, urinary metabolites are common to various active substances. A tiered approach is proposed for risk assessment. Tier I was a conservative screening for overall pyrethroid exposure, based on phenoxybenzoic acid metabolites. Subsequently, probabilistic approaches and more specific metabolites were used for refining the risk estimates. Exposure was based on 95th percentiles from HBM4EU aligned studies (2014-2021) covering children in Belgium, Cyprus, France, Israel, Slovenia, and The Netherlands and adults in France, Germany, Israel, and Switzerland. In all children populations, the 95th percentiles for 3-phenoxybenzoic acid (3-PBA) exceeded the screening value. The probabilistic refinement quantified the risk level of the most exposed population (Belgium) at 2% or between 1-0.1% depending on the assumptions. In the substance specific assessments, the 95th percentiles of urinary concentrations in the aligned studies were well below the respective human biomonitoring guidance values (HBM-GVs). Both information sets were combined for refining the combined risk. Overall, the HBM data suggest a low health concern, at population level, related to pyrethroid exposure for the populations covered by the studies, even though a potential risk for highly exposed children cannot be completely excluded. The proposed tiered approach, including a screening step and several refinement options, seems to be a promising tool of scientific and regulatory value in future.
Toxics. 2022 Aug 4;10(8):451.
http://hdl.handle.net/20.500.12105/15239
36006130
10.3390/toxics10080451
2305-6304
Toxics
HBM4EU
Biocides
Combined pyrethroid risk assessment
Guidance values
Human biomonitoring
Pesticides
Pyrethroids
Screening assessment
Tiered approach
Veterinary drugs
A Tiered Approach for Assessing Individual and Combined Risk of Pyrethroids Using Human Biomonitoring Data