2024-03-28T15:56:33Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/141092023-09-28T09:24:05Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_2053com_20.500.12105_2052col_20.500.12105_16990col_20.500.12105_16983col_20.500.12105_16974col_20.500.12105_16970col_20.500.12105_16968col_20.500.12105_16962col_20.500.12105_2054
00925njm 22002777a 4500
dc
Gómez-Acebo, Inés
author
Dierssen-Sotos, Trinidad
author
Palazuelos-Calderón, Camilo
author
Perez-Gomez, Beatriz
author
Amiano, Pilar
author
Guevara, Marcela
author
Molina, Antonio J
author
Domingo, Laia
author
Fernández-Ortiz, María
author
Moreno, Victor
author
Alguacil, Juan
author
Fernández-Tardón, Guillermo
author
Ibáñez, Josefa
author
Marcos-Gragera, Rafael
author
Diaz-Santos, Marian
author
Alonso, M Henar
author
Alonso-Molero, Jéssica
author
Castaño-Vinyals, Gemma
author
Palomo, Andrés García
author
Ardanaz, Eva
author
Molinuevo, Amaia
author
Aragonés, Nuria
author
Kogevinas, Manolis
author
Pollan-Santamaria, Marina
author
Llorca, Javier
author
2020-06
Purpose: The objective of this study is to analyse the relative survival with breast cancer in women diagnosed after new treatments were generalised and to ascertain the current effect that tumour characteristics such as grade, stage or subtype have on survival as well as the new AJCC-pathological prognostic score. Methods: The breast cancer MCC-Spain follow-up study is a prospective cohort study of 1685 incident breast cancer cases. Women between 20 and 85 years old were recruited between the years 2008 and 2013 in 18 hospitals located in 10 Spanish provinces and they have been followed until 2017/2018. Relative survival was estimated after 3, 5 and 8 years of follow-up using Ederer II method. In addition, Weibull regression adjusted by age, hospital, grade and stage was used to investigate prognosis factors. Results: Among components of TNM staging system, tumour size greater than 50 mm (i.e. T3 or T4) more than doubled the risk of dying, while N3 nodal involvement and presence of metastasis had a huge effect on mortality. The AJCC pathological prognostic score strongly correlated with survival; thus, hazard ratios increased as the score rose, being 2.31, 4.00, 4.94, 7.92, 2.26, 14.9 and 58.9 for scores IB, IIA, IIB, IIIA, IIIB, IIIC and IV, respectively. Conclusion: Both TNM staging and histological/molecular biomarkers are associated with overall survival in Spanish women with breast cancer; when both are combined in the AJCC pathological prognosis score, the prognostic value improved with risk indices that increased rapidly as the pathological prognosis score increased.
Breast Cancer Res Treat. 2020;181(3):667-678.
http://hdl.handle.net/20.500.12105/14109
32356254
10.1007/s10549-020-05600-x
1573-7217
Breast Cancer Research and Treatment
Breast cancer
Cohort
Epidemiology
MCC-spain
Relative survival
Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain study