2024-03-29T15:00:36Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/128952022-06-08T10:11:15Zcom_20.500.12105_2060com_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_2061
00925njm 22002777a 4500
dc
Monsalve-Castillo, Francisca
author
Chacín-Bonilla, Leonor
author
Atencio, Ricardo J
author
Espinoza, Leticia Porto
author
Costa-León, Luciana
author
Echevarria, Jose Manuel
author
2007-02
Previous studies have not found hepatitis C virus (HCV) infection in Amerindians from Western Venezuela. A survey of 254 Bari and Yukpa natives aged 10-60 years (mean +/- SD age = 35 +/- 5.4 years) from four communities, two Bari and two Yukpa, in this area were studied to assess the prevalence of antibodies to HCV (anti-HCV) and HCV RNA among these indigenous populations. Serum samples were examined initially for anti-HCV by a four generation enzyme-linked immunosorbent assay (ELISA). Reactive samples were then tested using a third generation recombinant immunoblot assay (RIBA-3). Viral RNA was investigated in all immunoblot-reactive samples by a nested polymerase chain reaction (PCR) method. Six (2.3%) of 254 natives were positive by ELISA, one (2.2%) of these reactive samples were positive by RIBA, and four (1.5%) were indeterminate. Only two (0.8%) were positive by PCR, corresponding to 1 (2.1%) of 47 inhabitants of a Yukpa community and to 1 (2.2%) of 45 subjects of a Bari community. Iatrogenic is thought to play a role in acquisition of the infection. The findings indicate a HCV focus of low endemicity and are compatible with a low degree of exposures of the natives to the virus. Studies are necessary to assess the risk factors for infection in these Amerindians.
Mem Inst Oswaldo Cruz . 2007 Feb;102(1):107-10
0074-0276
http://hdl.handle.net/20.500.12105/12895
17294009
10.1590/s0074-02762007000100018
Memorias do Instituto Oswaldo Cruz
hepatitis C virus
prevalence
Amerindians
Venezuela
Low prevalence of hepatitis C virus infection in Amerindians from Western Venezuela.