2024-03-29T00:20:26Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/128222023-04-28T19:47:42Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_2060com_20.500.12105_2052col_20.500.12105_16963col_20.500.12105_2061
00925njm 22002777a 4500
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del Rosal, Teresa
author
Baquero-Artigao, Fernando
author
Calvo, Cristina
author
Mellado, María J
author
Molina, Juan C
author
Santos, María del Mar
author
Cilleruelo, María J
author
Bueno, Mercedes
author
Storch de Gracia, Pilar
author
Terol, Covadonga
author
Roa, Miguel Á
author
Piñeiro, Roi
author
García López-Hortelano, Milagros
author
García-García, María Luz
author
Rodríguez, Sonia
author
Penín, María
author
Zarauza, Alejandro
author
Alvarado, Francisco
author
de Blas, Ana
author
Otheo, Enrique
author
Rodríguez, Alfonso
author
Herreros, María L
author
Tagarro, Alfredo
author
Grande, Luis
author
Ramos, José T
author
Maté, Irene
author
Muñoz, Cristina
author
Zafra, Miguel Á
author
Romero-Gómez, María P
author
Pérez-Fernández, Elia
author
Delgado, Alberto
author
Casas Flecha, Inmaculada
author
Cabezas, María E
author
2011-11
To describe the epidemiological and clinical characteristics of children hospitalized with 2009 pandemic influenza (pH1N1) in Madrid, Spain. We included patients less than 14 years of age admitted to one of 18 hospitals in Madrid, Spain, between May 1 and November 30, 2009 and diagnosed with pH1N1 by polymerase chain reaction. A retrospective chart review was conducted and data were compared by age, presence of high-risk medical conditions, and pediatric intensive care unit (PICU) admission.
A total of 517 pH1N1 cases were included for final analysis. One hundred and forty-two patients (27·5%) had predisposing underlying illnesses, with immunosuppression (36 children, 7%) and moderate persistent asthma (34, 6·6%) being the most common ones. Patients with underlying medical conditions had longer hospital stays [median 5, interquartile range (IQR) 3-8 days, versus median 4, IQR 3-6, P < 0·001] and required intensive care (20·4% versus 5·9%, P < 0·001) and mechanical ventilation more frequently than previously healthy children. Globally, intensive care was required for 51 patients (10%) and invasive mechanical ventilation for 12 (2%). Pediatric intensive care unit admission was significantly associated with abnormal initial chest X-ray [Odds Ratio (OR) 3·5, 95% confidence interval (CI) 1·5-8·5], underlying neurological condition (OR 3·1, CI 1·2-7·5) and immunosuppression (OR 2·9, 1·2-6·8). Five patients (0·9%) died; two with severe neurological disease, two with leukemia, and one with a malignant solid tumor. Children with underlying medical conditions experienced more severe pH1N1 disease. Risk factors for admission to the PICU included underlying neurological conditions, immunosuppression and abnormal initial chest X-ray.
Influenza Other Respir Viruses. 2011;5(6):e544-51.
http://hdl.handle.net/20.500.12105/12822
21781285
10.1111/j.1750-2659.2011.00272.x
1750-2659
Influenza and Other Respiratory Viruses
2009 pandemic influenza A (H1N1)
Hospitalizations
Pediatric influenza
PH1N1
Pandemic H1N1 influenza-associated hospitalizations in children in Madrid, Spain.