2024-03-28T18:46:21Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/123682023-10-13T12:31:05Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_2145com_20.500.12105_2144col_20.500.12105_16983col_20.500.12105_16977col_20.500.12105_16969col_20.500.12105_2146
00925njm 22002777a 4500
dc
Cortes-Canteli, Marta
author
Gispert, Juan Domingo
author
Salvadó, Gemma
author
Toribio-Fernandez, Raquel
author
Tristão-Pereira, Catarina
author
Falcon, Carles
author
Oliva, Belen
author
Mendiguren, Jose M
author
Fernandez-Friera, Leticia
author
Sanz, Javier
author
Garcia-Ruiz, Jose M
author
Fernandez-Ortiz, Antonio
author
Sanchez-Gonzalez, Javier
author
Ibáñez, Borja
author
Molinuevo, José Luis
author
Fuster, Valentin
author
2021-02-23
Atherosclerosis has been linked to cognitive decline in late life; however, the impact of cardiovascular risk factors (CVRFs) and subclinical atherosclerosis on brain metabolism at earlier stages remains unexplored.
This study sought to determine the association between brain metabolism, subclinical atherosclerosis, and CVRFs in middle-aged asymptomatic individuals.
This study included 547 asymptomatic middle-aged participants (50 ± 4 years, 82% men) from the PESA (Progression of Early Subclinical Atherosclerosis) study with evidence of subclinical atherosclerosis. Participants underwent 18F-fluorodeoxyglucose (FDG)-positron emission tomography. Global brain FDG uptake and voxel-wise analyses were used to evaluate the associations of cerebral metabolism with CVRFs and atherosclerotic plaque burden in carotids and femorals assessed by 3-dimensional vascular ultrasound.
Global FDG uptake showed an inverse correlation with 30-year Framingham Risk Score (FRS) (β = -0.15, p < 0.001). This association was mainly driven by the presence of hypertension (d = 0.36, p < 0.001). Carotid plaque burden was inversely associated with global brain FDG uptake (β = -0.16, p < 0.001), even after adjusting for 30-year FRS. Voxel-wise approaches revealed that the brain areas most strongly affected by hypometabolism in association with 30-year FRS, hypertension, and carotid plaque burden were parietotemporal regions (angular, supramarginal, and inferior/middle temporal gyri) and the cingulate gyrus.
In asymptomatic middle-aged individuals, cardiovascular risk is associated with brain hypometabolism, with hypertension being the modifiable CVRF showing the strongest association. Subclinical carotid plaque burden is also linked to reduced brain metabolism independently of CVRFs. Cerebral areas showing hypometabolism include those known to be affected in dementia. These data reinforce the need to control CVRFs early in life in order to potentially reduce the brain's midlife vulnerability to future cognitive dysfunction.
J Am Coll Cardiol. 2021; 77(7):888-898
0735-1097
http://hdl.handle.net/20.500.12105/12368
33602472
10.1016/j.jacc.2020.12.027
Journal of the American College of Cardiology
Subclinical Atherosclerosis and Brain Metabolism in Middle-Aged Individuals: The PESA Study.