2024-03-28T10:42:54Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/121562022-10-27T12:41:01Zcom_20.500.12105_2060com_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_2061
00925njm 22002777a 4500
dc
Resino, Salvador
author
Fernandez-Rodriguez, Amanda
author
Pineda-Tenor, Daniel
author
Gómez-Moreno, Ana Zaida
author
Sánchez-Ruano, Juan José
author
Artaza-Varasa, Tomas
author
Muñoz-Gómez, María José
author
Virseda-Berdices, Ana
author
Martin-Vicente, Maria
author
Martinez, Isidoro
author
Jimenez-Sousa, Maria Angeles
author
2021-01-28
TRPM5 (transient receptor potential cation channel subfamily M member 5) rs886277 polymorphism has been related to liver cirrhosis from different etiologies. The present study investigates the association of TRPM5 rs886277 polymorphism with liver fibrosis progression and cirrhosis development in chronic hepatitis C (CHC) patients.
We conducted a retrospective study of 208 non-cirrhotic patients with CHC, who had at least two liver stiffness measurements (LSM) with a separation of 12 months (baseline LSM (LSM1) and the last LSM (LSM2)). Two outcome variables were considered: (1) LSM2/LSM1 ratio; (2) cirrhosis progression (F4; LSM ≥ 12.5 kPa). DNA genotyping was done at the CeGen using a MassARRAY platform.
The follow-up time was similar irrespective of the rs886277 genotype (46.4 months in TT genotype, 46.4 months in CT genotype, and 49.2 months in CC genotype; p = 0.649). The highest LSM increases were found in patients with CC genotype compared with TT and CT genotypes (p = 0.044 and p = 0.038, respectively). The cirrhosis progression was higher in patients with CC genotype than TT genotype (p = 0.033). Thus, the rs886277 C allele was associated with higher cirrhosis progression (adjusted odds ratio (aOR) = 2.64; p = 0.014). Moreover, rs886277 CC genotype was also related to higher values of LSM2/LSM1 ratio (adjusted arithmetic mean ratio a(AMR) = 1.31; p = 0.001) and cirrhosis progression (aOR = 4.33; p = 0.027).
TRPM5 rs886277 polymorphism was associated with liver fibrosis progression and cirrhosis development among hepatitis C virus (HCV)-infected patients. Specifically, the rs886277 C allele and CC genotype were risk factors for advancing liver fibrosis and cirrhosis compared to the rs886277 T allele and CT/TT genotype, respectively.
J Clin Med. 2021 Jan 28;10(3):483.
2077-0383
http://hdl.handle.net/20.500.12105/12156
33525598
10.3390/jcm10030483
Journal of clinical medicine
Chronic hepatitis C
Hepatic fibrosis
Cirrhosis
Liver stiffness
TRPM5
SNPs
TRPM5 rs886277 Polymorphism Predicts Hepatic Fibrosis Progression in Non-Cirrhotic HCV-Infected Patients