2024-03-29T15:50:12Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/120002022-10-11T13:54:47Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_2145com_20.500.12105_2144col_20.500.12105_16982col_20.500.12105_2146
00925njm 22002777a 4500
dc
Rangel-Zuñiga, Oriol Alberto
author
Vals-Delgado, Cristina
author
Alcala-Diaz, Juan Francisco
author
Quintana-Navarro, Gracia M.
author
Krylova, Yelizaveta
author
Leon-Acuña, Ana
author
Luque, Raul Miguel
author
Gomez-Delgado, Francisco
author
Delgado-Lista, Javier
author
Ordovas, Jose M
author
Perez-Martinez, Pablo
author
Camargo, Antonio
author
Lopez-Miranda, Jose
author
2021-03-05
MicroRNAs (miRNAs) regulate the expression of genes associated with the development of diseases, including type 2 diabetes mellitus (T2DM). However, the use of miRNAs to predict T2DM remission has been poorly studied. Therefore, we aimed to investigate whether circulating miRNAs could be used to predict the probability of T2DM remission in patients with coronary heart disease. We included the newly diagnosed T2DM (n = 190) of the 1,002 patients from the CORDIOPREV study. Seventy-three patients reverted from T2DM after 5 years of dietary intervention with a low-fat or Mediterranean diet. Plasma levels of 56 miRNAs were measured by OpenArray. Generalized linear model, receiver operating characteristic (ROC), Cox regression, and pathway analyses were performed. ROC analysis based on clinical variables showed an area under the curve (AUC) of 0.66. After a linear regression analysis, seven miRNAs were identified as the most important variables in the group’s differentiation. The addition of these miRNAs to clinical variables showed an AUC of 0.79. Cox regression analysis using a T2DM remission score including miRNAs showed that high-score patients have a higher probability of T2DM remission (hazard ratio [HR]low versus high, 4.44). Finally, 26 genes involved in 10 pathways were related to the miRNAs. We have identified miRNAs (hsa-let-7b, hsa-miR-101, hsa-miR-130b-3p, hsa-miR-27a, hsa-miR-30a-5p, hsa-miR-375, and hsa-miR-486) that contribute to the prediction of T2DM remission in patients with coronary heart disease.
Mol Ther Nucleic Acids. 2021; 23(5):255-263
2162-2531
http://hdl.handle.net/20.500.12105/12000
10.1016/j.omtn.2020.11.001
Molecular Therapy - Nucleic Acids
A set of miRNAs predicts T2DM remission in patients with coronary heart disease: from the CORDIOPREV study