2024-03-28T11:26:57Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/118132023-08-31T06:51:54Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_2053com_20.500.12105_2052col_20.500.12105_16984col_20.500.12105_16982col_20.500.12105_16978col_20.500.12105_16973col_20.500.12105_16961col_20.500.12105_2054
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Lope Carvajal, Virginia
author
Guerrero-Zotano, Ángel
author
Casas, Ana
author
Baena-Cañada, José Manuel
author
Bermejo, Begoña
author
Perez-Gomez, Beatriz
author
Criado-Navarro, Inmaculada
author
Antolín, Silvia
author
Sánchez-Rovira, Pedro
author
Ramos-Vázquez, Manuel
author
Antón, Antonio
author
Castelló Pastor, Adela
author
García-Saénz, José Ángel
author
Muñoz, Montserrat
author
de Juan, Ana
author
Andrés, Raquel
author
Llombart-Cussac, Antonio
author
Hernando, Blanca
author
Franquesa, Rosa María
author
Caballero, Rosalia
author
Priego-Capote, Feliciano
author
Martín, Miguel
author
Pollan-Santamaria, Marina
author
2020-10-14
This study evaluates whether serum phospholipids fatty acids (PL-FAs) and markers of their endogenous metabolism are associated with breast cancer (BC) subtypes. EpiGEICAM is a Spanish multicenter matched case-control study. A lifestyle and food frequency questionnaire was completed by 1017 BC cases and healthy women pairs. Serum PL-FA percentages were measured by gas chromatography-mass spectrometry. Conditional and multinomial logistic regression models were used to quantify the association of PL-FA tertiles with BC risk, overall and by pathological subtype (luminal, HER2+ and triple negative). Stratified analyses by body mass index and menopausal status were also performed. Serum PL-FAs were measured in 795 (78%) pairs. Women with high serum levels of stearic acid (odds ratio (OR)T3vsT1 = 0.44; 95% confidence interval (CI) = 0.30-0.66), linoleic acid (ORT3vsT1 = 0.66; 95% CI = 0.49-0.90) and arachidonic to dihomo-γ-linolenic acid ratio (OR T3vsT1 = 0.64; 95% CI = 0.48-0.84) presented lower BC risk. Participants with high concentrations of palmitoleic acid (ORT3vsT1 = 1.65; 95% CI = 1.20-2.26), trans-ruminant palmitelaidic acid (ORT3vsT1 = 1.51; 95% CI = 1.12-2.02), trans-industrial elaidic acid (ORT3vsT1 = 1.52; 95% CI = 1.14-2.03), and high oleic to stearic acid ratio (ORT3vsT1 = 2.04; 95% CI = 1.45-2.87) showed higher risk. These associations were similar in all BC pathological subtypes. Our results emphasize the importance of analyzing fatty acids individually, as well as the desaturase activity indices.
Nutrients . 2020 Oct 14;12(10):3132.
http://hdl.handle.net/20.500.12105/11813
33066483
10.3390/nu12103132
2072-6643
Nutrients
EpiGEICAM
Breast cancer subtypes
Breast neoplasm
Desaturation indices
Fats
Serum Phospholipids Fatty Acids and Breast Cancer Risk by Pathological Subtype.