2024-03-29T09:26:38Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/116442023-07-12T06:35:27Zcom_20.500.12105_2067com_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_2068
00925njm 22002777a 4500
dc
Vorkamp, Katrin
author
Castaño, Argelia
author
Antignac, Jean-Philippe
author
Boada, Luis D
author
Cequier, Enrique
author
Covaci, Adrian
author
Esteban-Lopez, Marta
author
Haug, Line S
author
Kasper-Sonnenberg, Monika
author
Koch, Holger M
author
Pérez Luzardo, Octavio
author
Osīte, Agnese
author
Rambaud, Loïc
author
Pinorini, Maria-Teresa
author
Sabbioni, Gabriele
author
Thomsen, Cathrine
author
2021-01
The major purpose of human biomonitoring is the mapping and assessment of human exposure to chemicals. The European initiative HBM4EU has prioritized seven substance groups and two metals relevant for human exposure: Phthalates and substitutes (1,2-cyclohexane dicarboxylic acid diisononyl ester, DINCH), bisphenols, per- and polyfluoroalkyl substances (PFASs), halogenated and organophosphorous flame retardants (HFRs and OPFRs), polycyclic aromatic hydrocarbons (PAHs), arylamines, cadmium and chromium. As a first step towards comparable European-wide data, the most suitable biomarkers, human matrices and analytical methods for each substance group or metal were selected from the scientific literature, based on a set of selection criteria. The biomarkers included parent compounds of PFASs and HFRs in serum, of bisphenols and arylamines in urine, metabolites of phthalates, DINCH, OPFRs and PAHs in urine as well as metals in blood and urine, with a preference to measure Cr in erythrocytes representing Cr (VI) exposure. High performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) was the method of choice for bisphenols, PFASs, the HFR hexabromocyclododecane (HBCDD), phenolic HFRs as well as the metabolites of phthalates, DINCH, OPFRs and PAHs in urine. Gas chromatographic (GC) methods were selected for the remaining compounds, e.g. GC-low resolution MS with electron capture negative ionization (ECNI) for HFRs. Both GC-MS and LC-MS/MS were suitable for arylamines. New developments towards increased applications of GC-MS/MS may offer alternatives to GC-MS or LC-MS/MS approaches, e.g. for bisphenols. The metals were best determined by inductively coupled plasma (ICP)-MS, with the particular challenge of avoiding interferences in the Cd determination in urine. The evaluation process revealed research needs towards higher sensitivity and non-invasive sampling as well as a need for more stringent quality assurance/quality control applications and assessments.
Environ Int . 2021 Jan;146:106082.
0160-4120
http://hdl.handle.net/20.500.12105/11644
33227583
10.1016/j.envint.2020.106082
Environment international
Bisphenols
Flame retardants
HBM4EU
Metals
Per- and polyfluoroalkyl substances
Phthalates
Biomarkers, matrices and analytical methods targeting human exposure to chemicals selected for a European human biomonitoring initiative.