2024-03-28T20:30:55Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/110652023-10-06T12:01:18Zcom_20.500.12105_2145com_20.500.12105_2051com_20.500.12105_2144col_20.500.12105_2146
00925njm 22002777a 4500
dc
Bär, Christian
author
Chatterjee, Shambhabi
author
Falcão Pires, Inês
author
Rodrigues, Patrícia
author
Sluijter, Joost P G
author
Boon, Reinier A
author
Nevado, Rosa M
author
Andres, Vicente
author
Sansonetti, Marida
author
de Windt, Leon
author
Ciccarelli, Michele
author
Hamdani, Nazha
author
Heymans, Stephane
author
Figuinha Videira, Raquel
author
Tocchetti, Carlo G
author
Giacca, Mauro
author
Zacchigna, Serena
author
Engelhardt, Stefan
author
Dimmeler, Stefanie
author
Madonna, Rosalinda
author
Thum, Thomas
author
2020-09-01
Vast parts of mammalian genomes are actively transcribed, predominantly giving rise to non-coding RNA (ncRNA) transcripts including microRNAs, long ncRNAs, and circular RNAs among others. Contrary to previous opinions that most of these RNAs are non-functional molecules, they are now recognized as critical regulators of many physiological and pathological processes including those of the cardiovascular system. The discovery of functional ncRNAs has opened up new research avenues aiming at understanding ncRNA-related disease mechanisms as well as exploiting them as novel therapeutics in cardiovascular therapy. In this review, we give an update on the current progress in ncRNA research, particularly focusing on cardiovascular physiological and disease processes, which are under current investigation at the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart. This includes a range of topics such as extracellular vesicle-mediated communication, neurohormonal regulation, inflammation, cardiac remodelling, cardio-oncology as well as cardiac development and regeneration, collectively highlighting the wide-spread involvement and importance of ncRNAs in the cardiovascular system.
Cardiovasc Res. 2020; 116(11):1805-1819
http://hdl.handle.net/20.500.12105/11065
32638021
10.1093/cvr/cvaa195
1755-3245
Cardiovascular research
Non-coding RNAs: update on mechanisms and therapeutic targets from the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart.