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dc.contributor.authorKordowitzki, Pawel
dc.contributor.authorHamdi, Meriem
dc.contributor.authorDerevyanko, Aksinya
dc.contributor.authorRizos, Dimitrios
dc.contributor.authorBlasco, Maria Antonia 
dc.date.accessioned2020-05-05T14:47:47Z
dc.date.available2020-05-05T14:47:47Z
dc.date.issued2020-04-27
dc.identifier.citationAging (Albany NY). 2020 ;12(8):7576-7584.es_ES
dc.identifier.issn1945-4589es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/9907
dc.descriptionDr P. Kordowitzki was supported by KNOW consortium (Poland MS&HE, Decision No. 05-1/KNOW2/2015) and by a special statutory fund of DRI&P IAR&FR PAS in Olsztynes_ES
dc.description.abstractMaternal aging-associated reduction of oocyte viability is a common feature in mammals, but more research is needed to counteract this process. In women, the first aging phenotype appears with a decline in reproductive function, and the follicle number gradually decreases from menarche to menopause. Cows can be used as a model of early human embryonic development and reproductive aging because both species share a very high degree of similarity during follicle selection, cleavage, and blastocyst formation. Recently, it has been proposed that the main driver of aging is the mammalian target of rapamycin (mTOR) signaling rather than reactive oxygen species. Based on these observations, the study aimed to investigate for the first time the possible role of rapamycin on oocyte maturation, embryonic development, and telomere length in the bovine species, as a target for future strategies for female infertility caused by advanced maternal age. The 1nm rapamycin in vitro treatment showed the best results for maturation rates (95.21±4.18%) of oocytes and was considered for further experiments. In conclusion, rapamycin influenced maturation rates of oocytes in a concentration-dependent manner. Our results also suggest a possible link between mTOR, telomere maintenance, and bovine blastocyst formation.es_ES
dc.language.isoenges_ES
dc.publisherImpact Journals es_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectBlastocystses_ES
dc.subjectOocyteses_ES
dc.subjectRapamycines_ES
dc.subjectReproductive aginges_ES
dc.subjectTelomerees_ES
dc.titleThe effect of rapamycin on bovine oocyte maturation success and metaphase telomere length maintenancees_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.identifier.pubmedID32339158es_ES
dc.format.volume12es_ES
dc.format.number8es_ES
dc.format.page7576-7584es_ES
dc.identifier.doi10.18632/aging.103126es_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn1945-4589es_ES
dc.relation.publisherversionhttps://doi.org/10.18632/aging.103126.es_ES
dc.identifier.journalAginges_ES
dc.repisalud.institucionCNIOes_ES
dc.repisalud.orgCNIOCNIO::Grupos de investigación::Grupo de Telómeros y Telomerasaes_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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Atribución-NoComercial-CompartirIgual 4.0 Internacional
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