Mostrar el registro sencillo del ítem

dc.contributor.authorMenendez-Gutierrez, Maria Piedad 
dc.contributor.authorRicote, Mercedes 
dc.date.accessioned2020-05-05T09:52:24Z
dc.date.available2020-05-05T09:52:24Z
dc.date.issued2017-06
dc.identifier.citationCell Mol Life Sci. 2017; 74(12):2135-2149es_ES
dc.identifier.issn1420-682Xes_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/9891
dc.description.abstractRetinoid X receptors (RXRs) form a unique subclass within the nuclear receptor (NR) superfamily of ligand-dependent transcription factors. RXRs are obligatory partners for a number of other NRs, placing RXRs in a coordinating role at the crossroads of multiple signaling pathways. In addition, RXRs can function as self-sufficient homodimers. Recent advances have revealed RXRs as novel regulators of osteoclastogenesis and bone remodeling. This review outlines the versatility of RXR action in the control of transcription of bone-forming osteoblasts and bone-resorbing osteoclasts, both through heterodimerization with other NRs and through RXR homodimerization. RXR signaling is currently a major therapeutic target and, therefore, knowledge of how RXR signaling affects bone remodeling creates enormous potential for the translation of basic research findings into successful clinical therapies to increase bone mass and improve bone quality.es_ES
dc.description.sponsorshipWe thank S. Bartlett (CNIC) for editorial assistance. Some of the work reported in this review was supported by a grant from the Spanish Ministry of Economy and Competitiveness (SAF2015-64287) to M. Ricote. The CNIC is supported by the Spanish Ministry of Economy and Competitiveness (MINECO) and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (MINECO award SEV-2015-0505). We apologize to our many colleagues for not being able to cite all relevant references owing to space limitations.es_ES
dc.language.isoenges_ES
dc.publisherSpringer es_ES
dc.type.hasVersionAMes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject9-cis retinoic acides_ES
dc.subjectAgonistses_ES
dc.subjectAntagonistses_ES
dc.subjectBexarotenees_ES
dc.subjectBone resorptiones_ES
dc.subjectHeterodimerses_ES
dc.subjectHomodimerses_ES
dc.subjectMAFBes_ES
dc.subjectOsteoporosises_ES
dc.subjectPermissivees_ES
dc.subjectRexinoidses_ES
dc.subjectSkeletones_ES
dc.subject.meshAnimals es_ES
dc.subject.meshBone Resorption es_ES
dc.subject.meshHumans es_ES
dc.subject.meshModels, Biological es_ES
dc.subject.meshProtein Multimerization es_ES
dc.subject.meshRetinoid X Receptors es_ES
dc.subject.meshBone Remodeling es_ES
dc.titleThe multi-faceted role of retinoid X receptor in bone remodelinges_ES
dc.typejournal articlees_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.identifier.pubmedID28105491es_ES
dc.format.volume74es_ES
dc.format.number12es_ES
dc.format.page2135-2149es_ES
dc.identifier.doi10.1007/s00018-017-2458-4es_ES
dc.contributor.funderMinisterio de Economía y Competitividad (España) 
dc.contributor.funderFundación ProCNIC 
dc.description.peerreviewedes_ES
dc.identifier.e-issn1420-9071es_ES
dc.relation.publisherversionhttps://doi.org/10.1007/s00018-017-2458-4es_ES
dc.identifier.journalCellular and molecular life sciences : CMLSes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Señalización de los Receptores Nucleareses_ES
dc.repisalud.institucionCNICes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SEV-2015-0505es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2015-64287es_ES
dc.rights.accessRightsopen accesses_ES


Ficheros en el ítem

Acceso Abierto
Thumbnail

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Attribution-NonCommercial-NoDerivatives 4.0 Internacional