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dc.contributor.authorEsher, Shannon K
dc.contributor.authorZaragoza, Oscar 
dc.contributor.authorAlspaugh, James Andrew
dc.identifier.citationMem Inst Oswaldo Cruz. 2018;113(7):e180057.es_ES
dc.description.abstractCryptococcus neoformans is an opportunistic pathogenic yeast that causes serious infections, most commonly of the central nervous system (CNS). C. neoformans is mainly found in the environment and acquired by inhalation. It could be metaphorically imagined that cryptococcal disease is a "journey" for the microorganism that starts in the environment, where this yeast loads its suitcase with virulence traits. C. neoformans first encounters the infected mammalian host in the lungs, a site in which it must choose the right elements from its "virulence suitcase" to survive the pulmonary immune response. However, the lung is often only the first stop in this journey, and in some individuals the fungal trip continues to the brain. To enter the brain, C. neoformans must "open" the main barrier that protects this organ, the blood brain barrier (BBB). Once in the brain, C. neoformans expresses a distinct set of protective attributes that confers a strong neurotropism and the ability to cause brain colonisation. In summary, C. neoformans is a unique fungal pathogen as shown in its ability to survive in the face of multiple stress factors and to express virulence factors that contribute to the development of disease.es_ES
dc.description.sponsorshipSKE and JAA were supported by NIH (grants R01 AI074677, R01 GM121458-01 and P01 AI104533); JAA was a Burroughs Wellcome Fund New Investigator in Molecular Pathogenic Mycology; OZ is funded by grant SAF2014-5366R from the Spanish Ministry for Economics, Industry and Competitivity and MPY1356/15 from the Instituto de Salud Carlos III.es_ES
dc.publisherFundação Oswaldo Cruz (Fiocruz) es_ES
dc.subject.meshAnimals es_ES
dc.subject.meshCentral Nervous System Bacterial Infections es_ES
dc.subject.meshCryptococcosis es_ES
dc.subject.meshCryptococcus neoformans es_ES
dc.subject.meshDisease Models, Animales_ES
dc.subject.meshHumans es_ES
dc.subject.meshVirulence es_ES
dc.subject.meshBlood-Brain Barrier es_ES
dc.titleCryptococcal pathogenic mechanisms: a dangerous trip from the environment to the braines_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.contributor.funderMinisterio de Economía, Industria y Competitividad (España) 
dc.contributor.funderInstituto de Salud Carlos III 
dc.identifier.journalMemorias do Instituto Oswaldo Cruzes_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/R01 AI074677es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/R01 GM121458-01es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/ P01 AI104533es_ES
dc.rights.accessRightsopen accesses_ES

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Atribución-NoComercial-CompartirIgual 4.0 Internacional
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