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dc.contributor.authorAlfranca, Arantzazu 
dc.contributor.authorCampanero, Miguel R
dc.contributor.authorRedondo, Juan Miguel 
dc.date.accessioned2020-04-29T14:50:04Z
dc.date.available2020-04-29T14:50:04Z
dc.date.issued2018-10
dc.identifier.citationTrends Mol Med. 2018; 24(10):852-37es_ES
dc.identifier.issn14714914es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/9808
dc.description.abstractLentiviral vectors (LVs) transduce quiescent cells and provide stable integration to maintain transgene expression. Several approaches have been adopted to optimize LV safety profiles. Similarly, LV targeting has been tailored through strategies including the modification of envelope components, the use of specific regulatory elements, and the selection of appropriate administration routes. Models of aortic disease based on a single injection of pleiotropic LVs have been developed that efficiently transduce the three aorta layers in wild type mice. This approach allows the dissection of pathways involved in aortic aneurysm formation and the identification of targets for gene therapy in aortic diseases. LVs provide a fast, efficient, and affordable alternative to genetically modified mice to study disease mechanisms and develop therapeutic tools.es_ES
dc.language.isoenges_ES
dc.publisherCell Presses_ES
dc.relation.isversionofPostprintes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectaortic aneurysmes_ES
dc.subjectdisease modelses_ES
dc.subjectgene therapyes_ES
dc.subjectlentiviral vectorses_ES
dc.subjectviral targetinges_ES
dc.subject.meshADAMTS1 Protein es_ES
dc.subject.meshAnimals es_ES
dc.subject.meshAortic Aneurysm es_ES
dc.subject.meshClinical Trials as Topic es_ES
dc.subject.meshDisease Models, Animales_ES
dc.subject.meshGene Expression Regulation es_ES
dc.subject.meshGenetic Therapy es_ES
dc.subject.meshGenetic Vectors es_ES
dc.subject.meshHumans es_ES
dc.subject.meshImmunity, Innate es_ES
dc.subject.meshLentivirus es_ES
dc.subject.meshMice es_ES
dc.subject.meshPatient Safety es_ES
dc.subject.meshRNA, Small Interfering es_ES
dc.subject.meshTransduction, Genetices_ES
dc.subject.meshTransgenes es_ES
dc.titleNew Methods for Disease Modeling Using Lentiviral Vectorses_ES
dc.typeArtículoes_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.identifier.pubmedID30213701es_ES
dc.format.volume24es_ES
dc.format.number10es_ES
dc.format.page825-837es_ES
dc.identifier.doi10.1016/j.molmed.2018.08.001es_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn1471-499Xes_ES
dc.identifier.journalTrends in molecular medicinees_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Regulación Génica en Remodelado Vascular e Inflamaciónes_ES
dc.repisalud.institucionCNICes_ES
dc.relation.projectIDhttps://doi.org/10.1016/j.molmed.2018.08.001es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
This item is licensed under a: Attribution-NonCommercial-NoDerivatives 4.0 Internacional