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dc.contributor.authorAdrover, Jose M 
dc.contributor.authorAroca-Crevillen, Alejandra 
dc.contributor.authorCrainiciuc, Georgiana 
dc.contributor.authorOstos, Fernando
dc.contributor.authorRojas, Yeny 
dc.contributor.authorRubio-Ponce, Andrea 
dc.contributor.authorCilloniz, Catia
dc.contributor.authorBonzon-Kulichenko, Elena 
dc.contributor.authorCalvo, Enrique 
dc.contributor.authorRico, Daniel 
dc.contributor.authorMoro, Maria Angeles
dc.contributor.authorWeber, Christian
dc.contributor.authorLizasoaín, Ignacio
dc.contributor.authorTorres, Antoni
dc.contributor.authorRuiz-Cabello, Jesus 
dc.contributor.authorVazquez, Jesus 
dc.contributor.authorHidalgo, Andrés 
dc.date.accessioned2020-04-29T09:19:19Z
dc.date.available2020-04-29T09:19:19Z
dc.date.issued2020-02
dc.identifier.citationNat Immunol. 2020; 21(2):135-144es_ES
dc.identifier.issn1529-2908es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/9805
dc.description.abstractThe antimicrobial functions of neutrophils are facilitated by a defensive armamentarium of proteins stored in granules, and by the formation of neutrophil extracellular traps (NETs). However, the toxic nature of these structures poses a threat to highly vascularized tissues, such as the lungs. Here, we identified a cell-intrinsic program that modified the neutrophil proteome in the circulation and caused the progressive loss of granule content and reduction of the NET-forming capacity. This program was driven by the receptor CXCR2 and by regulators of circadian cycles. As a consequence, lungs were protected from inflammatory injury at times of day or in mouse mutants in which granule content was low. Changes in the proteome, granule content and NET formation also occurred in human neutrophils, and correlated with the incidence and severity of respiratory distress in pneumonia patients. Our findings unveil a 'disarming' strategy of neutrophils that depletes protein stores to reduce the magnitude of inflammation.es_ES
dc.description.sponsorshipWe thank members of the Comparative Medicine Unit and Advanced Microscopy Unit at CNIC. This study was supported by Intramural grants from the Severo Ochoa program (IGP-SO), a grant from Fundació La Marató de TV3 (120/C/2015-20153032), grant SAF2015-65607-R from Ministerio de Ciencia, Investigacion y Universidades (MCIU) with cofunding from Fondo Europeo de Desarrollo Regional, grant RTI2018-095497-B-I00 from MCIU and HR17_00527 from Fundación La Caixa (to A.H.), and fellowship BES-2013-065550 from MCIU (to J.M.A.), fellowship from La Caixa Foundation (ID 100010434, code LCF/BQ/DR19/11740022, to A.A.-C.) and fellowship Health-PERIS 2016–2020 (to C.C.) Funds were also obtained from Instituto de Salud Carlos III (FIS PI17/01601, to I.L.) and SAF2015-68632-R from MCIU (to M.A.M.); Wellcome Trust Seed Award in Science (206103/Z/17/Z, to D.R.), SFB1123-A1/A10 from Deutsche Forschungsgemeinschaft and ERC-AdG 692511 (to C.W.); SAF2017-84494-C2-R and Programa Red Guipuzcoana de Ciencia, Tecnología e Información 2018-CIEN-000058-01 (to J.R.-C.). Work at CIC biomaGUNE was performed under the Maria de Maeztu Units of Excellence Program from the Spanish State Research Agency (MDM-2017-0720). C.W. is a van de Laar professor of atherosclerosis. The CNIC is supported by the MCIU and the Pro-CNIC Foundation, and is a Severo Ochoa Center of Excellence (MEIC award SEV-2015-0505).es_ES
dc.language.isoenges_ES
dc.publisherSpringer-Naturees_ES
dc.relation.isversionofPostprintes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.meshAnimals es_ES
dc.subject.meshCell Degranulation es_ES
dc.subject.meshCircadian Rhythm es_ES
dc.subject.meshCytoplasmic Granules es_ES
dc.subject.meshExtracellular Traps es_ES
dc.subject.meshHumans es_ES
dc.subject.meshInflammation es_ES
dc.subject.meshMice es_ES
dc.subject.meshNeutrophils es_ES
dc.subject.meshPneumonia es_ES
dc.subject.meshProteome es_ES
dc.subject.meshRespiratory Distress Syndrome, Adult es_ES
dc.titleProgrammed 'disarming' of the neutrophil proteome reduces the magnitude of inflammationes_ES
dc.typeArtículoes_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.identifier.pubmedID31932813es_ES
dc.format.volume21es_ES
dc.format.number2es_ES
dc.format.page135-144es_ES
dc.identifier.doi10.1038/s41590-019-0571-2es_ES
dc.contributor.funderFundació La Maratóes_ES
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España)es_ES
dc.contributor.funderFundación La Caixaes_ES
dc.contributor.funderEuropean Regional Development Fund (ERDF/FEDER)es_ES
dc.contributor.funderInstituto de Salud Carlos III - ISCIIIes_ES
dc.contributor.funderWellcome Trustes_ES
dc.contributor.funderDeutsche Forschungsgemeinschaftes_ES
dc.contributor.funderEuropean Research Counciles_ES
dc.contributor.funderFundación ProCNICes_ES
dc.description.peerreviewedes_ES
dc.embargo.terms2020-08-01es_ES
dc.identifier.e-issn1529-2916es_ES
dc.relation.publisherversionhttps://doi.org/10.1038/s41590-019-0571-2es_ES
dc.identifier.journalNature immunologyes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Imagen de la Inflamación Cardiovascular y la Respuesta Inmunees_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Proteómica cardiovasculares_ES
dc.repisalud.orgCNICCNIC::Unidades técnicas::Proteómica / Metabolómicaes_ES
dc.repisalud.orgCNICCNIC::Unidades técnicas::Imagen Avanzadaes_ES
dc.repisalud.institucionCNICes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SEV-2015-0505es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2015-65607-Res_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/RTI2018-095497-B-I00es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI17/01601es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2015-68632-Res_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/692511es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2017-84494-C2-Res_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/MDM-2017-0720es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/embargoedAccesses_ES


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
This item is licensed under a: Attribution-NonCommercial-NoDerivatives 4.0 Internacional