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dc.contributor.authorMoreno-García, Alexandra
dc.contributor.authorKun, Alejandra
dc.contributor.authorCalero, Olga 
dc.contributor.authorMedina, Miguel
dc.contributor.authorCalero, Miguel
dc.identifier.citationFront Neurosci. 2018 Jul 5;12:464.es_ES
dc.description.abstractDespite aging being by far the greatest risk factor for highly prevalent neurodegenerative disorders, the molecular underpinnings of age-related brain changes are still not well understood, particularly the transition from normal healthy brain aging to neuropathological aging. Aging is an extremely complex, multifactorial process involving the simultaneous interplay of several processes operating at many levels of the functional organization. The buildup of potentially toxic protein aggregates and their spreading through various brain regions has been identified as a major contributor to these pathologies. One of the most striking morphologic changes in neurons during normal aging is the accumulation of lipofuscin (LF) aggregates, as well as, neuromelanin pigments. LF is an autofluorescent lipopigment formed by lipids, metals and misfolded proteins, which is especially abundant in nerve cells, cardiac muscle cells and skin. Within the Central Nervous System (CNS), LF accumulates as aggregates, delineating a specific senescence pattern in both physiological and pathological states, altering neuronal cytoskeleton and cellular trafficking and metabolism, and being associated with neuronal loss, and glial proliferation and activation. Traditionally, the accumulation of LF in the CNS has been considered a secondary consequence of the aging process, being a mere bystander of the pathological buildup associated with different neurodegenerative disorders. Here, we discuss recent evidence suggesting the possibility that LF aggregates may have an active role in neurodegeneration. We argue that LF is a relevant effector of aging that represents a risk factor or driver for neurodegenerative disorders.es_ES
dc.description.sponsorshipThis work was supported by grant SA1F2016-78603-R from Spanish Ministry of Economy, Industry and Competitiveness (MINECO) to MM and MC, the National Programme for the Promotion of Talent and its Employability from MINECO (AM-G), and the Spanish CIBERNED network (OC, MM, MC).es_ES
dc.publisherFrontiers Media es_ES
dc.subjectOxidative stresses_ES
dc.subjectProtein depositses_ES
dc.titleAn Overview of the Role of Lipofuscin in Age-Related Neurodegenerationes_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.contributor.funderMinisterio de Economía, Industria y Competitividad (España) 
dc.contributor.funderCentro de Investigación Biomedica en Red - CIBER
dc.identifier.journalFrontiers in neurosciencees_ES
dc.repisalud.centroISCIII::Unidad Funcional de Investigación de Enfermedades Crónicas (UFIEC)es_ES
dc.rights.accessRightsopen accesses_ES

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Atribución 4.0 Internacional
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