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dc.contributor.authorIborra, Salvador 
dc.contributor.authorMartinez-Lopez, Maria 
dc.contributor.authorCueto, Francisco J. 
dc.contributor.authorConde-Garrosa, Ruth 
dc.contributor.authordel Fresno, Carlos 
dc.contributor.authorIzquierdo-Fernandez, Helena María 
dc.contributor.authorAbram, Clare L
dc.contributor.authorMori, Daiki
dc.contributor.authorCampos-Martín, Yolanda
dc.contributor.authorReguera, Rosa María
dc.contributor.authorKemp, Benjamin
dc.contributor.authorYamasaki, Sho
dc.contributor.authorRobinson, Matthew J
dc.contributor.authorSoto, Manuel
dc.contributor.authorLowell, Clifford A
dc.contributor.authorSancho, David 
dc.date.accessioned2020-04-23T08:57:30Z
dc.date.available2020-04-23T08:57:30Z
dc.date.issued2016-10
dc.identifier.citationImmunity. 2016; 45(4):788-801es_ES
dc.identifier.issn1074-7613es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/9709
dc.description.abstractC-type lectin receptors sense a diversity of endogenous and exogenous ligands that may trigger differential responses. Here, we have found that human and mouse Mincle bind to a ligand released by Leishmania, a eukaryote parasite that evades an effective immune response. Mincle-deficient mice had milder dermal pathology and a tenth of the parasite burden compared to wild-type mice after Leishmania major intradermal ear infection. Mincle deficiency enhanced adaptive immunity against the parasite, correlating with increased activation, migration, and priming by Mincle-deficient dendritic cells (DCs). Leishmania triggered a Mincle-dependent inhibitory axis characterized by SHP1 coupling to the FcRγ chain. Selective loss of SHP1 in CD11c+ cells phenocopies enhanced adaptive immunity to Leishmania. In conclusion, Leishmania shifts Mincle to an inhibitory ITAM (ITAMi) configuration that impairs DC activation. Thus, ITAMi can be exploited for immune evasion by a pathogen and may represent a paradigm for ITAM-coupled receptors sensing self and non-self.es_ES
dc.description.sponsorshipCNIC; Spanish Ministry of Economy and Competitiveness (MINECO) [SAF-2013-42920R]; European Commission [635122-PROCROP H2020]; European Research Council [ERC-2010-StG 260414]; MINECO; Pro-CNIC Foundation; Severo Ochoa Center of Excellence (MINECO award) [SEV-2015-0505]; [SAF2015-74561-JIN]es_ES
dc.language.isoenges_ES
dc.publisherCell Presses_ES
dc.relation.isversionofPostprintes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.meshAdaptive Immunity es_ES
dc.subject.meshAnimals es_ES
dc.subject.meshCD11c Antigen es_ES
dc.subject.meshCell Differentiation es_ES
dc.subject.meshCell Line, Tumor es_ES
dc.subject.meshDendritic Cells es_ES
dc.subject.meshImmunoreceptor Tyrosine-Based Activation Motif es_ES
dc.subject.meshLectins, C-Type es_ES
dc.subject.meshLeishmania major es_ES
dc.subject.meshMembrane Proteins es_ES
dc.subject.meshMice es_ES
dc.subject.meshMice, Inbred C57BL es_ES
dc.subject.meshMice, Transgenic es_ES
dc.subject.meshProtein Tyrosine Phosphatase, Non-Receptor Type 6 es_ES
dc.subject.meshReceptors, Fc es_ES
dc.subject.meshSignal Transduction es_ES
dc.titleLeishmania Uses Mincle to Target an Inhibitory ITAM Signaling Pathway in Dendritic Cells that Dampens Adaptive Immunity to Infectiones_ES
dc.typeArtículoes_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.identifier.pubmedID27742545es_ES
dc.format.volume45es_ES
dc.format.number4es_ES
dc.format.page788-801es_ES
dc.identifier.doi10.1016/j.immuni.2016.09.012es_ES
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
dc.contributor.funderEuropean Commisiones_ES
dc.contributor.funderEuropean Research Counciles_ES
dc.contributor.funderFundación ProCNICes_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn1097-4180es_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.immuni.2016.09.012es_ES
dc.identifier.journalImmunityes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Inmunobiologíaes_ES
dc.repisalud.institucionCNICes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SEV-2015-0505es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/635122es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/260414es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
This item is licensed under a: Attribution-NonCommercial-NoDerivatives 4.0 Internacional