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dc.contributor.author | Garcia-Lunar, Ines | |
dc.contributor.author | Pereda, Daniel | |
dc.contributor.author | Santiago, Evelyn | |
dc.contributor.author | Solanes, Nuria | |
dc.contributor.author | Nuche, Jorge | |
dc.contributor.author | Ascaso, Maria | |
dc.contributor.author | Bobí, Joaquim | |
dc.contributor.author | Sierra, Federico | |
dc.contributor.author | Dantas, Ana Paula | |
dc.contributor.author | Galan-Arriola, Carlos | |
dc.contributor.author | San Antonio, Rodolfo | |
dc.contributor.author | Sánchez-Quintana, Damián | |
dc.contributor.author | Sanchez-Gonzalez, Javier | |
dc.contributor.author | Barberá, Joan Albert | |
dc.contributor.author | Rigol, Montserrat | |
dc.contributor.author | Fuster, Valentin | |
dc.contributor.author | Ibáñez, Borja | |
dc.contributor.author | Sabaté, Manel | |
dc.contributor.author | Garcia-Alvarez, Ana | |
dc.date.accessioned | 2020-04-08T13:32:49Z | |
dc.date.available | 2020-04-08T13:32:49Z | |
dc.date.issued | 2019-01 | |
dc.identifier.citation | Basic Res Cardiol. 2019; 114(2):5 | es_ES |
dc.identifier.issn | 0300-8428 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/9491 | |
dc.description.abstract | There is scarce evidence for pulmonary artery denervation (PADN) as a potential treatment for chronic postcapillary pulmonary hypertension (PH). We aimed to perform a proof-of-concept of PADN in a translational model of chronic PH. Nineteen pigs with chronic postcapillary PH (secondary to pulmonary vein banding) were randomized to surgical-PADN (using bipolar radiofrequency clamps) or sham procedure. Additionally, 6 healthy animals underwent percutaneous-PADN to compare the pulmonary artery (PA) lesion generated with both approaches. In the surgical-PADN arm, hemodynamic evaluation and cardiac magnetic resonance (CMR) were performed at baseline and at 2 and 3-month follow-up. Histological assessment was carried out at the completion of the protocol. Eighteen pigs (6 following surgical-PADN, 6 sham and 6 percutaneous-PADN) completed the protocol. A complete transmural PA lesion was demonstrated using surgical clamps, whereas only focal damage to adventitial fibers was observed after percutaneous-PADN. In the surgical-PADN arm, the hemodynamic profile did not significantly differ between groups neither at baseline [mean pulmonary artery pressure (mPAP) median values of 32.0 vs. 27.5 mmHg, P = 0.394 and indexed pulmonary vascular resistance (iPVR) 5.9 vs. 4.7 WU m2, P = 0.394 for PADN/sham groups, respectively] nor at any follow-up (mPAP of 35.0 vs. 35.0 mmHg, P = 0.236 and iPVR of 8.3 vs. 6.7 WU m2, P = 0.477 at third month in PADN/sham groups, respectively). Surgical-PADN was not associated with any benefit in RV anatomy or function on CMR/histology. In a large-animal model of chronic postcapillary PH, transmural PADN with surgical clamps was associated with a neutral pulmonary hemodynamic effect. | es_ES |
dc.description.sponsorship | This work has been partially funded by the grant "Translational research project from the Sociedad Espanola de Cardiologia" (to Dr. Garcia-Alvarez) and by an unrestricted grant from Medtronic. The CNIC is supported by the Ministerio de Ciencia, Innovacion y Universidades and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (SEV-2015-0505). IDIBAPS belongs to the CERCA Programme and receives partial funding from the Generalitat de Catalunya. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Springer | es_ES |
dc.type.hasVersion | AM | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Denervation | es_ES |
dc.subject | Magnetic resonance imaging | es_ES |
dc.subject | Pulmonary hypertension | es_ES |
dc.subject | Treatment | es_ES |
dc.subject.mesh | Animals | es_ES |
dc.subject.mesh | Denervation | es_ES |
dc.subject.mesh | Disease Models, Animal | es_ES |
dc.subject.mesh | Pulmonary Artery | es_ES |
dc.subject.mesh | Random Allocation | es_ES |
dc.subject.mesh | Swine | es_ES |
dc.subject.mesh | Translational Medical Research | es_ES |
dc.subject.mesh | Hypertension, Pulmonary | es_ES |
dc.title | Effect of pulmonary artery denervation in postcapillary pulmonary hypertension: results of a randomized controlled translational study | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.identifier.pubmedID | 30635778 | es_ES |
dc.format.volume | 114 | es_ES |
dc.format.number | 2 | es_ES |
dc.format.page | 5 | es_ES |
dc.identifier.doi | 10.1007/s00395-018-0714-x | es_ES |
dc.contributor.funder | Sociedad Española de Cardiología | |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (España) | |
dc.contributor.funder | Fundación ProCNIC | |
dc.contributor.funder | Government of Catalonia (España) | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1435-1803 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1007/s00395-018-0714-x | es_ES |
dc.identifier.journal | Basic research in cardiology | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Laboratorio Traslacional para la Imagen y Terapia Cardiovascular | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SEV-2015-0505 | es_ES |
dc.rights.accessRights | open access | es_ES |