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dc.contributor.authorGarcia-Lunar, Ines 
dc.contributor.authorPereda, Daniel 
dc.contributor.authorSantiago, Evelyn 
dc.contributor.authorSolanes, Nuria
dc.contributor.authorNuche, Jorge 
dc.contributor.authorAscaso, Maria
dc.contributor.authorBobí, Joaquim
dc.contributor.authorSierra, Federico 
dc.contributor.authorDantas, Ana Paula
dc.contributor.authorGalan-Arriola, Carlos 
dc.contributor.authorSan Antonio, Rodolfo
dc.contributor.authorSánchez-Quintana, Damián
dc.contributor.authorSanchez-Gonzalez, Javier 
dc.contributor.authorBarberá, Joan Albert
dc.contributor.authorRigol, Montserrat
dc.contributor.authorFuster, Valentin 
dc.contributor.authorIbanez, Borja 
dc.contributor.authorSabaté, Manel
dc.contributor.authorGarcia-Alvarez, Ana
dc.identifier.citationBasic Res Cardiol. 2019; 114(2):5es_ES
dc.description.abstractThere is scarce evidence for pulmonary artery denervation (PADN) as a potential treatment for chronic postcapillary pulmonary hypertension (PH). We aimed to perform a proof-of-concept of PADN in a translational model of chronic PH. Nineteen pigs with chronic postcapillary PH (secondary to pulmonary vein banding) were randomized to surgical-PADN (using bipolar radiofrequency clamps) or sham procedure. Additionally, 6 healthy animals underwent percutaneous-PADN to compare the pulmonary artery (PA) lesion generated with both approaches. In the surgical-PADN arm, hemodynamic evaluation and cardiac magnetic resonance (CMR) were performed at baseline and at 2 and 3-month follow-up. Histological assessment was carried out at the completion of the protocol. Eighteen pigs (6 following surgical-PADN, 6 sham and 6 percutaneous-PADN) completed the protocol. A complete transmural PA lesion was demonstrated using surgical clamps, whereas only focal damage to adventitial fibers was observed after percutaneous-PADN. In the surgical-PADN arm, the hemodynamic profile did not significantly differ between groups neither at baseline [mean pulmonary artery pressure (mPAP) median values of 32.0 vs. 27.5 mmHg, P = 0.394 and indexed pulmonary vascular resistance (iPVR) 5.9 vs. 4.7 WU m2, P = 0.394 for PADN/sham groups, respectively] nor at any follow-up (mPAP of 35.0 vs. 35.0 mmHg, P = 0.236 and iPVR of 8.3 vs. 6.7 WU m2, P = 0.477 at third month in PADN/sham groups, respectively). Surgical-PADN was not associated with any benefit in RV anatomy or function on CMR/histology. In a large-animal model of chronic postcapillary PH, transmural PADN with surgical clamps was associated with a neutral pulmonary hemodynamic effect.es_ES
dc.description.sponsorshipThis work has been partially funded by the grant "Translational research project from the Sociedad Espanola de Cardiologia" (to Dr. Garcia-Alvarez) and by an unrestricted grant from Medtronic. The CNIC is supported by the Ministerio de Ciencia, Innovacion y Universidades and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (SEV-2015-0505). IDIBAPS belongs to the CERCA Programme and receives partial funding from the Generalitat de Catalunya.es_ES
dc.subjectMagnetic resonance imaginges_ES
dc.subjectPulmonary hypertensiones_ES
dc.subject.meshAnimals es_ES
dc.subject.meshDenervation es_ES
dc.subject.meshDisease Models, Animales_ES
dc.subject.meshPulmonary Artery es_ES
dc.subject.meshRandom Allocation es_ES
dc.subject.meshSwine es_ES
dc.subject.meshTranslational Medical Research es_ES
dc.subject.meshHypertension, Pulmonary es_ES
dc.titleEffect of pulmonary artery denervation in postcapillary pulmonary hypertension: results of a randomized controlled translational studyes_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.contributor.funderSociedad Española de Cardiologíaes_ES
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España)es_ES
dc.contributor.funderFundación ProCNICes_ES
dc.contributor.funderGeneralitat de Catalunyaes_ES
dc.identifier.journalBasic research in cardiologyes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Laboratorio Traslacional para la Imagen y Terapia Cardiovasculares_ES

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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
This item is licensed under a: Attribution-NonCommercial-NoDerivatives 4.0 Internacional