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dc.contributor.authorCortes-Canteli, Marta 
dc.contributor.authorIadecola, Costantino
dc.date.accessioned2020-04-03T11:59:13Z
dc.date.available2020-04-03T11:59:13Z
dc.date.issued2020-03-03
dc.identifier.citationJ Am Coll Cardiol. 2020; 75(8):942-951es_ES
dc.identifier.issn07351097es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/9442
dc.description.abstractAlzheimer's disease, the leading cause of dementia in the elderly, is a neurodegenerative condition characterized by accumulation of amyloid plaques and neurofibrillary tangles in the brain. However, age-related vascular changes accompany or even precede the development of Alzheimer's pathology, raising the possibility that they may have a pathogenic role. This review provides an appraisal of the alterations in cerebral and systemic vasculature, the heart, and hemostasis that occur in Alzheimer's disease and their relationships to cognitive impairment. Although the molecular pathogenesis of these alterations remains to be defined, amyloid-β is a likely contributor in the brain as in the heart. Collectively, the evidence suggests that vascular pathology is a likely pathogenic contributor to age-related dementia, including Alzheimer's disease, inextricably linked to disease onset and progression. Consequently, the contribution of vascular factors should be considered in preventive, diagnostic, and therapeutic approaches to address one of the major health challenges of our time.es_ES
dc.description.sponsorshipDr. Cortes-Canteli is supported by a Miguel Servet type I research contract (CP16/00174 and MS16/00174); a Fondo de Investigación Sanitaria project (PI17/00590) from the Instituto de Salud Carlos III (ISCIII), Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain; European Regional Development Funds (FEDER “Una manera de hacer Europa”); and European Social Funds (FSE “El FSE invierte en tu futuro”). The CNIC is supported by the ISCIII, the Spanish Ministerio de Ciencia, Innovación y Universidades, and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (SEV-2015-0505). Dr. Iadecola has served on the strategic advisory board for Broadview Ventures; and is supported by the National Institutes of Health (grants R01-NS34179, R37-NS089323, R01-NS100447, R01-NS095441, and R01-NS/HL37853).es_ES
dc.language.isoenges_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAtherosclerosises_ES
dc.subjectBlood-brain barrieres_ES
dc.subjectCerebral blood flowes_ES
dc.subjectDementiaes_ES
dc.subjectHypertensiones_ES
dc.subjectVascular dysfunctiones_ES
dc.titleAlzheimer's Disease and Vascular Aging: JACC Focus Seminares_ES
dc.typejournal articlees_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.identifier.pubmedID32130930es_ES
dc.format.volume75es_ES
dc.format.number8es_ES
dc.format.page942-951es_ES
dc.identifier.doi10.1016/j.jacc.2019.10.062es_ES
dc.contributor.funderInstituto de Salud Carlos III 
dc.contributor.funderUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) 
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España) 
dc.contributor.funderFundación ProCNIC 
dc.contributor.funderNational Institutes of Health (Estados Unidos) 
dc.description.peerreviewedes_ES
dc.identifier.e-issn1558-3597es_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.jacc.2019.10.062es_ES
dc.identifier.journalJournal of the American College of Cardiologyes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Imagen Cardiovascular y Estudios Poblacionaleses_ES
dc.repisalud.institucionCNICes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SEV-2015-0505es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/CP16/00174es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/MS16/00174es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI17/00590es_ES
dc.rights.accessRightsopen accesses_ES


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Attribution-NonCommercial-NoDerivatives 4.0 Internacional