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dc.contributor.author | Cortes-Canteli, Marta | |
dc.contributor.author | Iadecola, Costantino | |
dc.date.accessioned | 2020-04-03T11:59:13Z | |
dc.date.available | 2020-04-03T11:59:13Z | |
dc.date.issued | 2020-03-03 | |
dc.identifier.citation | J Am Coll Cardiol. 2020; 75(8):942-951 | es_ES |
dc.identifier.issn | 07351097 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/9442 | |
dc.description.abstract | Alzheimer's disease, the leading cause of dementia in the elderly, is a neurodegenerative condition characterized by accumulation of amyloid plaques and neurofibrillary tangles in the brain. However, age-related vascular changes accompany or even precede the development of Alzheimer's pathology, raising the possibility that they may have a pathogenic role. This review provides an appraisal of the alterations in cerebral and systemic vasculature, the heart, and hemostasis that occur in Alzheimer's disease and their relationships to cognitive impairment. Although the molecular pathogenesis of these alterations remains to be defined, amyloid-β is a likely contributor in the brain as in the heart. Collectively, the evidence suggests that vascular pathology is a likely pathogenic contributor to age-related dementia, including Alzheimer's disease, inextricably linked to disease onset and progression. Consequently, the contribution of vascular factors should be considered in preventive, diagnostic, and therapeutic approaches to address one of the major health challenges of our time. | es_ES |
dc.description.sponsorship | Dr. Cortes-Canteli is supported by a Miguel Servet type I research contract (CP16/00174 and MS16/00174); a Fondo de Investigación Sanitaria project (PI17/00590) from the Instituto de Salud Carlos III (ISCIII), Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain; European Regional Development Funds (FEDER “Una manera de hacer Europa”); and European Social Funds (FSE “El FSE invierte en tu futuro”). The CNIC is supported by the ISCIII, the Spanish Ministerio de Ciencia, Innovación y Universidades, and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (SEV-2015-0505). Dr. Iadecola has served on the strategic advisory board for Broadview Ventures; and is supported by the National Institutes of Health (grants R01-NS34179, R37-NS089323, R01-NS100447, R01-NS095441, and R01-NS/HL37853). | es_ES |
dc.language.iso | eng | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Atherosclerosis | es_ES |
dc.subject | Blood-brain barrier | es_ES |
dc.subject | Cerebral blood flow | es_ES |
dc.subject | Dementia | es_ES |
dc.subject | Hypertension | es_ES |
dc.subject | Vascular dysfunction | es_ES |
dc.title | Alzheimer's Disease and Vascular Aging: JACC Focus Seminar | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.identifier.pubmedID | 32130930 | es_ES |
dc.format.volume | 75 | es_ES |
dc.format.number | 8 | es_ES |
dc.format.page | 942-951 | es_ES |
dc.identifier.doi | 10.1016/j.jacc.2019.10.062 | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (España) | |
dc.contributor.funder | Fundación ProCNIC | |
dc.contributor.funder | National Institutes of Health (Estados Unidos) | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1558-3597 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/j.jacc.2019.10.062 | es_ES |
dc.identifier.journal | Journal of the American College of Cardiology | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Imagen Cardiovascular y Estudios Poblacionales | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SEV-2015-0505 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/CP16/00174 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/MS16/00174 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI17/00590 | es_ES |
dc.rights.accessRights | open access | es_ES |