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dc.contributor.authorHoshino, Masahiro
dc.contributor.authorHamaya, Rikuta
dc.contributor.authorKanaji, Yoshihisa
dc.contributor.authorKanno, Yoshinori
dc.contributor.authorHada, Masahiro
dc.contributor.authorYamaguchi, Masao
dc.contributor.authorSumino, Yohei
dc.contributor.authorHirano, Hidenori
dc.contributor.authorHorie, Tomoki
dc.contributor.authorUsui, Eisuke
dc.contributor.authorSugiyama, Tomoyo
dc.contributor.authorMurai, Tadashi
dc.contributor.authorLee, Tetsumin
dc.contributor.authorYonetsu, Taishi
dc.contributor.authorLee, Joo Myung
dc.contributor.authorChoi, Ki Hong
dc.contributor.authorHwang, Doyeon
dc.contributor.authorPark, Jonghanne
dc.contributor.authorJung, Ji-Hyun
dc.contributor.authorKim, Hyung Yoon
dc.contributor.authorJung, Hae Won
dc.contributor.authorCho, Yun-Kyeong
dc.contributor.authorYoon, Hyuck-Jun
dc.contributor.authorSong, Young Bin
dc.contributor.authorHahn, Joo-Yong
dc.contributor.authorDoh, Joon-Hyung
dc.contributor.authorNam, Chang-Wook
dc.contributor.authorShin, Eun-Seok
dc.contributor.authorHur, Seung-Ho
dc.contributor.authorMejía-Rentería, Hernán
dc.contributor.authorLauri, Francesco
dc.contributor.authorGoto, Sonoka
dc.contributor.authorMacaya, Fernando
dc.contributor.authorMcInerney, Angela
dc.contributor.authorGravina, Giacomo
dc.contributor.authorVera, Rafael
dc.contributor.authorGonzalo, Nieves
dc.contributor.authorJimenez-Quevedo, Pilar
dc.contributor.authorNuñez-Gil, Ivan
dc.contributor.authorSalinas, Pablo
dc.contributor.authorNombela-Franco, Luis
dc.contributor.authorDel Trigo, Maria
dc.contributor.authorFernandez-Ortiz, Antonio 
dc.contributor.authorMacaya, Carlos
dc.contributor.authorKoo, Bon-Kwon
dc.contributor.authorEscaned, Javier 
dc.contributor.authorKakuta, Tsunekazu
dc.date.accessioned2020-04-03T11:46:39Z
dc.date.available2020-04-03T11:46:39Z
dc.date.issued2020-02-18
dc.identifier.citationJ Am Heart Assoc. 2020; 9(4):e014458es_ES
dc.identifier.issn2047-9980es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/9441
dc.description.abstractBackground Sex-specific differences may influence prognosis after deferred revascularization following fractional flow reserve (FFR) measurement. This study sought to investigate the sex differences in long-term prognosis of patients with deferred revascularization following FFR assessment. Methods and Results A total of 879 patients (879 vessels) with deferred revascularization with FFR >0.75 who underwent FFR and coronary flow reserve measurements were enrolled from 3 countries (Korea, Japan, and Spain). Long-term outcomes were assessed in 649 men and 230 women by the patient-oriented composite outcome (POCO, a composite of any death, any myocardial infarction, and any revascularization). We applied inverse-probability weighting based on propensity scores to account for differences at baseline between women and men (age, hyperlipidemia, diabetes mellitus, diameter stenosis, lesion length, multivessel disease, FFR, coronary flow reserve. The median follow-up duration was 1855 days (745-1855 days). Median FFR values were 0.88 (0.83-0.93) in men and 0.89 (0.85-0.94) in women, respectively. The occurrences of POCO were significantly high in men compared with that in women (10.5% versus 4.2%, P=0.007). Kaplan-Meier analysis revealed that women had a significantly lower risk of POCO (χ2=7.2, P=0.007). Multivariate COX proportional hazards regression analysis revealed that age, male, diabetes mellitus, diameter stenosis, lesion length, and coronary flow reserve were independent predictors of POCO. After applying IPW, the hazard ratio of males for POCO was 2.07 (95% CI, 1.07-4.04, P=0.032). Conclusions This large multinational study reveals that long-term outcome differs between women and men in favor of women after FFR-guided revascularization deferral. Clinical Trial Registration URL: http://www.ClinicalTrials.gov. Unique identifier: NCT02186093.es_ES
dc.language.isoenges_ES
dc.publisherAmerican Heart Associationes_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectcoronary flow reservees_ES
dc.subjectfractional flow reservees_ES
dc.subjectmicrovascular dysfunctiones_ES
dc.subjectsex differenceses_ES
dc.titleSex Differences in Long-Term Outcomes in Patients With Deferred Revascularization Following Fractional Flow Reserve Assessment: International Collaboration Registry of Comprehensive Physiologic Evaluationes_ES
dc.typeArtículoes_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.identifier.pubmedID32063120es_ES
dc.format.volume9es_ES
dc.format.number4es_ES
dc.format.pagee014458es_ES
dc.identifier.doi10.1161/JAHA.119.014458es_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn2047-9980es_ES
dc.relation.publisherversionhttps://doi.org/10.1161/JAHA.119.014458es_ES
dc.identifier.journalJournal of the American Heart Associationes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Laboratorio Traslacional para la Imagen y Terapia Cardiovasculares_ES
dc.repisalud.institucionCNICes_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
This item is licensed under a: Attribution-NonCommercial-NoDerivatives 4.0 Internacional