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dc.contributor.authorEsteva-Socias, Margalida
dc.contributor.authorArtiga, María Jesús 
dc.contributor.authorBahamonde, Olga
dc.contributor.authorBelar, Oihana
dc.contributor.authorBermudo, Raquel
dc.contributor.authorCastro, Erika
dc.contributor.authorEscámez, Teresa
dc.contributor.authorFraga, Máximo
dc.contributor.authorJauregui-Mosquera, Laura
dc.contributor.authorNovoa, Isabel
dc.contributor.authorPeiró-Chova L 
dc.contributor.authorRejón, Juan-David
dc.contributor.authorRuiz-Miró, María
dc.contributor.authorVieiro-Balo, Paula
dc.contributor.authorVillar-Campo, Virginia
dc.contributor.authorZazo, Sandra
dc.contributor.authorRábano, Alberto
dc.contributor.authorVillena, Cristina
dc.date.accessioned2020-03-27T13:26:09Z
dc.date.available2020-03-27T13:26:09Z
dc.date.issued2019-11-12
dc.identifier.citationJ Transl Med. 2019 Nov;17(1):370es_ES
dc.identifier.issn1479-5876es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/9351
dc.description.abstractThe purpose of the present work is to underline the importance of obtaining a standardized procedure to ensure and evaluate both clinical and research usability of human tissue samples. The study, which was carried out by the Biospecimen Science Working Group of the Spanish Biobank Network, is based on a general overview of the current situation about quality assurance in human tissue biospecimens. It was conducted an exhaustive review of the analytical techniques used to evaluate the quality of human tissue samples over the past 30 years, as well as their reference values if they were published, and classified them according to the biomolecules evaluated: (i) DNA, (ii) RNA, and (iii) soluble or/and fixed proteins for immunochemistry. More than 130 publications released between 1989 and 2019 were analysed, most of them reporting results focused on the analysis of tumour and biopsy samples. A quality assessment proposal with an algorithm has been developed for both frozen tissue samples and formalin-fixed paraffin-embedded (FFPE) samples, according to the expected quality of sample based on the available pre-analytical information and the experience of the participants in the Working Group. The high heterogeneity of human tissue samples and the wide number of pre-analytic factors associated to quality of samples makes it very difficult to harmonize the quality criteria. However, the proposed method to assess human tissue sample integrity and antigenicity will not only help to evaluate whether stored human tissue samples fit for the purpose of biomarker development, but will also allow to perform further studies, such as assessing the impact of different pre-analytical factors on very well characterized samples or evaluating the readjustment of tissue sample collection, processing and storing procedures. By ensuring the quality of the samples used on research, the reproducibility of scientific results will be guaranteed.es_ES
dc.description.sponsorshipThis work was funded by the Ministerio de Ciencia, Innovacion y Universidades of Spain and Instituto de Salud Carlos III (PI16/00528, PI16/00946, PI16/01207 and PI16/01276), co-funded by the Spanish Biobank Network (PT13/0010/0030, PT17/0015/0001, PT17/0015/0021, PT17/0015/0049, PT17/0015/0018, PT17/0015/0002, PT17/0015/0016, PT17/0015/0038, PT17/0015/0027, PT17/0015/0004, PT17/0015/0047, PT17/0015/0014, PT17/0015/0041, and PT17/0015/0006), European Regional Development Fund (FEDER) "A way to make Europe" and granted by Conselleria d'Innovacio, Recerca i Turisme del Govern de les Illes Balears (TEC/002/2017).es_ES
dc.language.isoenges_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectBiobankes_ES
dc.subjectBiospecimen sciencees_ES
dc.subjectPre-analytical variableses_ES
dc.subjectQualityes_ES
dc.subjectTissuees_ES
dc.titleIn search of an evidence-based strategy for quality assessment of human tissue samples: report of the tissue Biospecimen Research Working Group of the Spanish Biobank Networkes_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.identifier.pubmedID31718661es_ES
dc.format.volume17es_ES
dc.format.number1es_ES
dc.format.page370es_ES
dc.identifier.doi10.1186/s12967-019-2124-8es_ES
dc.contributor.funderMinisterio de Ciencia, Innovacion y Universidades (Spain)es_ES
dc.contributor.funderInstituto de Salud Carlos III - ISCIII (España)es_ES
dc.contributor.funderSpanish Biobank Networkes_ES
dc.contributor.funderEuropean Regional Development Fund (FEDER)es_ES
dc.contributor.funderGovern de les Illes Balearses_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn1479-5876es_ES
dc.relation.publisherversionhttps://doi.org/10.1186/s12967-019-2124-8.es_ES
dc.identifier.journalJournal of translational medicinees_ES
dc.repisalud.institucionCNIOes_ES
dc.repisalud.orgCNIOCNIO::Unidades técnicas::Biobancoes_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/PI16/00528es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/PI16/00946es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/PI16/01207es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/PT17/0015/0001es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/PT17/0015/0049es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/PT17/0015/0018es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/PT17/0015/0016es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/PT17/0015/0038es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/PT17/0015/0027es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/PT17/0015/0004es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/PT17/0015/0047es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/PT17/0015/0014es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/PT17/0015/0041es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/PT17/0015/0006es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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Atribución-NoComercial-CompartirIgual 4.0 Internacional
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