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dc.contributor.authorCarril-Ajuria, Lucía
dc.contributor.authorSantos, María
dc.contributor.authorRoldán-Romero, Juan María
dc.contributor.authorRodriguez Antona, Cristina 
dc.contributor.authorde Velasco, Guillermo
dc.date.accessioned2020-03-26T13:19:33Z
dc.date.available2020-03-26T13:19:33Z
dc.date.issued2019-12-19
dc.identifier.citationCancers (Basel). 2019 ;12(1).es_ES
dc.identifier.issn2072-6694es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/9342
dc.description.abstractRenal cell carcinoma (RCC) is the most frequent kidney solid tumor, the clear cell RCC (ccRCC) being the major histological subtype. The probability of recurrence and the clinical behavior of ccRCC will greatly depend on the different clinical and histopathological features, already incorporated to different scoring systems, and on the genomic landscape of the tumor. In this sense, ccRCC has for a long time been known to be associated to the biallelic inactivation of Von Hippel-Lindau (VHL) gene which causes aberrant hypoxia inducible factor (HIF) accumulation. Recently, next generation-sequencing technologies have provided the bases for an in-depth molecular characterization of ccRCC, identifying additional recurrently mutated genes, such as PBRM1 (≈40-50%), SETD2 (≈12%), or BAP1 (≈10%). PBRM1, the second most common mutated gene in ccRCC after VHL, is a component of the SWI/SNF chromatin remodeling complex. Different studies have investigated the biological consequences and the potential role of PBRM1 alterations in RCC prognosis and as a drug response modulator, although some results are contradictory. In the present article, we review the current evidence on PBRM1 as potential prognostic and predictive marker in both localized and metastatic RCC.es_ES
dc.language.isoenges_ES
dc.publisherMPDIes_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectPBRM1es_ES
dc.subjectbiomarkeres_ES
dc.subjectpolybromo-1es_ES
dc.subjectpredictive rolees_ES
dc.subjectprognosises_ES
dc.subjectrenal cell carcinomaes_ES
dc.titlePrognostic and Predictive Value of PBRM1 in Clear Cell Renal Cell Carcinomaes_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.identifier.pubmedID31861590es_ES
dc.format.volume12es_ES
dc.format.number1es_ES
dc.format.page16es_ES
dc.identifier.doi10.3390/cancers12010016es_ES
dc.description.peerreviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.3390/cancers12010016.es_ES
dc.identifier.journalCancerses_ES
dc.repisalud.institucionCNIOes_ES
dc.repisalud.orgCNIOCNIO::Grupos de investigación::Grupo de Cáncer Endocrino Hereditarioes_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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Atribución-NoComercial-CompartirIgual 4.0 Internacional
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