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dc.contributor.authorCordero, Joaquín G
dc.contributor.authorGarcía-Escudero, Ramón
dc.contributor.authorAvila, Jesús
dc.contributor.authorGargini, Ricardo 
dc.contributor.authorGarcía-Escudero, Vega
dc.identifier.citationOxid Med Cell Longev. 2018 Feb 20;2018:5010741.es_ES
dc.description.abstractAlzheimer's disease is a proteinopathy characterized by accumulation of hyperphosphorylated Tau and β-amyloid. Autophagy is a physiological process by which aggregated proteins and damaged organelles are eliminated through lysosomal digestion. Autophagy deficiency has been demonstrated in Alzheimer's patients impairing effective elimination of aggregates and damaged mitochondria, leading to their accumulation, increasing their toxicity and oxidative stress. In the present study, we demonstrated by microarray analysis the downregulation of fundamental autophagy and mitophagy pathways in Alzheimer's patients. The benefits of the Mediterranean diet on Alzheimer's disease and cognitive impairment are well known, attributing this effect to several polyphenols, such as oleuropein aglycone (OLE), present in extra virgin olive oil. OLE is able to induce autophagy, achieving a decrease of aggregated proteins and a reduction of cognitive impairment in vivo. This effect is caused by the modulation of several pathways including the AMPK/mTOR axis and the activation of autophagy gene expression mediated by sirtuins and histone acetylation or EB transcription factor. We propose that supplementation of diet with extra virgin olive oil might have potential benefits for Alzheimer's patients by the induction of autophagy by OLE.es_ES
dc.description.sponsorshipThis work was supported by the Ministerio de Economía y Competitividad (SAF 2011 program, project 24841) from Spain and the Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED, ISCIII, JA). The AECC Scientific Foundation has financed Ricardo Gargini. The authors would like to specially acknowledge Gladys Sanchez Gonzalez for English editing.es_ES
dc.publisherHindawi es_ES
dc.subject.meshAcetates es_ES
dc.subject.meshAlzheimer Disease es_ES
dc.subject.meshAnimals es_ES
dc.subject.meshAutophagy es_ES
dc.subject.meshCyclopentane Monoterpenes es_ES
dc.subject.meshHumans es_ES
dc.subject.meshPyrans es_ES
dc.subject.meshTOR Serine-Threonine Kinases es_ES
dc.titleBenefit of Oleuropein Aglycone for Alzheimer's Disease by Promoting Autophagyes_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.contributor.funderMinisterio de Economía y Competitividad (España) 
dc.contributor.funderCentro de Investigación Biomedica en Red - CIBER
dc.contributor.funderAsociación Española Contra el Cáncer 
dc.identifier.journalOxidative medicine and cellular longevityes_ES
dc.repisalud.centroISCIII::Unidad Funcional de Investigación de Enfermedades Crónicas (UFIEC)es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF 2011 program, project 24841es_ES
dc.rights.accessRightsopen accesses_ES

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Atribución 4.0 Internacional
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