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dc.contributor.author | Jimenez-Sousa, Maria Angeles | |
dc.contributor.author | Liu, Pilar | |
dc.contributor.author | Medrano, Luz Maria | |
dc.contributor.author | Fernandez-Rodriguez, Amanda | |
dc.contributor.author | Almansa, Raquel | |
dc.contributor.author | Gómez-Sánchez, Esther | |
dc.contributor.author | Rico, Lucía | |
dc.contributor.author | Lorenzo, Mario | |
dc.contributor.author | Fadrique, Alejandra | |
dc.contributor.author | Tamayo, Eduardo | |
dc.contributor.author | Resino, Salvador | |
dc.date.accessioned | 2020-02-28T07:56:51Z | |
dc.date.available | 2020-02-28T07:56:51Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Sci Rep. 2018 Feb 9;8(1):2698. | es_ES |
dc.identifier.issn | 2045-2322 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/9153 | |
dc.description.abstract | The aim of this study was to investigate the relationship between the CD14 rs2569190 polymorphism and death related to septic shock in white European patients who underwent major cardiac or abdominal surgery. We carried out a retrospective study in 205 septic shock patients. The septic shock diagnosis was established by international consensus definitions. The outcome variable was the death within 28, 60 and 90 days after septic shock diagnosis. The CD14 rs2569190 polymorphism was analyzed by Agena Bioscience's MassARRAY platform. For the genetic association analysis with survival was selected a recessive inheritance model (GG vs. AA/AG). One hundred thirteen out of 205 patients (55.1%) died with a survival median of 39 days (95%CI = 30.6; 47.4). Patients with rs2569190 GG genotype had shorter survival probability than rs2569190 AA/AG genotype at 60 days (62.3% vs 50%; p = 0.035), and 90 days (62.3% vs 52.6%; p = 0.046). The rs2569190 GG genotype was associated with increased risk of septic shock-related death in the first 60 days (adjusted hazard ratio (aHR) = 1.67; p = 0.016) and 90 days (aHR = 1.64; p = 0.020) compared to rs2569190 AA/AG genotype. In conclusion, the presence of CD14 rs2569190 GG genotype was associated with death in shock septic patients who underwent major surgery. Further studies with bigger sample size are required to verify this relationship. | es_ES |
dc.description.sponsorship | The authors thank the Spanish National Genotyping Center (CEGEN-PRB2-ISCIII) for providing SNP genotyping services (http://www.cegen.org). It is supported by grant PT13/0001, ISCIII-SGEFI/FEDER. We also acknowledge the patients in this study for their participation. This work has been supported by grants given by Instituto de Salud Carlos III (grant numbers PI15/01451 to ET), “Gerencia de Salud, Consejería de Sanidad, Junta de Castilla y Leon” [grant number GRS 463/A/10 and 773/A/13 to ET], and PFIZER [grant number CT25-ESP01-01 to SR]. MAJS, LMM, and AFR are supported by “Instituto de Salud Carlos III” [grant numbers CD13/00013, CD14/00002, and CP14CIII/00010; respectively]. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Nature Publishing Group | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject.mesh | Aged | es_ES |
dc.subject.mesh | Alleles | es_ES |
dc.subject.mesh | Cardiac Surgical Procedures | es_ES |
dc.subject.mesh | Case-Control Studies | es_ES |
dc.subject.mesh | European Continental Ancestry Group | es_ES |
dc.subject.mesh | Female | es_ES |
dc.subject.mesh | Gene Frequency | es_ES |
dc.subject.mesh | Genotype | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Lipopolysaccharide Receptors | es_ES |
dc.subject.mesh | Male | es_ES |
dc.subject.mesh | Middle Aged | es_ES |
dc.subject.mesh | Polymorphism, Single Nucleotide | es_ES |
dc.subject.mesh | Retrospective Studies | es_ES |
dc.subject.mesh | Risk Factors | es_ES |
dc.subject.mesh | Sepsis | es_ES |
dc.subject.mesh | Shock, Septic | es_ES |
dc.title | Association of CD14 rs2569190 polymorphism with mortality in shock septic patients who underwent major cardiac or abdominal surgery: A retrospective study | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 29426837 | es_ES |
dc.format.volume | 8 | es_ES |
dc.format.number | 1 | es_ES |
dc.format.page | 2698 | es_ES |
dc.identifier.doi | 10.1038/s41598-018-20766-7 | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | |
dc.contributor.funder | Junta de Castilla y León (España) | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 2045-2322 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1038/s41598-018-20766-7 | es_ES |
dc.identifier.journal | Scientific reports | es_ES |
dc.repisalud.centro | ISCIII::Centro Nacional de Microbiología | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/ PT13/0001 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI15/01451 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/GRS 463/A/10 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/773/A/13 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/CT25-ESP01-01 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/CD13/00013 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/CD14/00002 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/CP14CIII/00010 | es_ES |
dc.rights.accessRights | open access | es_ES |