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dc.contributor.authorJimenez-Sousa, Maria Angeles 
dc.contributor.authorLiu, Pilar
dc.contributor.authorMedrano, Luz Maria 
dc.contributor.authorFernandez-Rodriguez, Amanda 
dc.contributor.authorAlmansa, Raquel
dc.contributor.authorGómez-Sánchez, Esther
dc.contributor.authorRico, Lucía
dc.contributor.authorLorenzo, Mario
dc.contributor.authorFadrique, Alejandra
dc.contributor.authorTamayo, Eduardo
dc.contributor.authorResino, Salvador 
dc.date.accessioned2020-02-28T07:56:51Z
dc.date.available2020-02-28T07:56:51Z
dc.date.issued2018
dc.identifier.citationSci Rep. 2018 Feb 9;8(1):2698.es_ES
dc.identifier.issn2045-2322es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/9153
dc.description.abstractThe aim of this study was to investigate the relationship between the CD14 rs2569190 polymorphism and death related to septic shock in white European patients who underwent major cardiac or abdominal surgery. We carried out a retrospective study in 205 septic shock patients. The septic shock diagnosis was established by international consensus definitions. The outcome variable was the death within 28, 60 and 90 days after septic shock diagnosis. The CD14 rs2569190 polymorphism was analyzed by Agena Bioscience's MassARRAY platform. For the genetic association analysis with survival was selected a recessive inheritance model (GG vs. AA/AG). One hundred thirteen out of 205 patients (55.1%) died with a survival median of 39 days (95%CI = 30.6; 47.4). Patients with rs2569190 GG genotype had shorter survival probability than rs2569190 AA/AG genotype at 60 days (62.3% vs 50%; p = 0.035), and 90 days (62.3% vs 52.6%; p = 0.046). The rs2569190 GG genotype was associated with increased risk of septic shock-related death in the first 60 days (adjusted hazard ratio (aHR) = 1.67; p = 0.016) and 90 days (aHR = 1.64; p = 0.020) compared to rs2569190 AA/AG genotype. In conclusion, the presence of CD14 rs2569190 GG genotype was associated with death in shock septic patients who underwent major surgery. Further studies with bigger sample size are required to verify this relationship.es_ES
dc.description.sponsorshipThe authors thank the Spanish National Genotyping Center (CEGEN-PRB2-ISCIII) for providing SNP genotyping services (http://www.cegen.org). It is supported by grant PT13/0001, ISCIII-SGEFI/FEDER. We also acknowledge the patients in this study for their participation. This work has been supported by grants given by Instituto de Salud Carlos III (grant numbers PI15/01451 to ET), “Gerencia de Salud, Consejería de Sanidad, Junta de Castilla y Leon” [grant number GRS 463/A/10 and 773/A/13 to ET], and PFIZER [grant number CT25-ESP01-01 to SR]. MAJS, LMM, and AFR are supported by “Instituto de Salud Carlos III” [grant numbers CD13/00013, CD14/00002, and CP14CIII/00010; respectively].es_ES
dc.language.isoenges_ES
dc.publisherNature Publishing Group es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.meshAged es_ES
dc.subject.meshAlleles es_ES
dc.subject.meshCardiac Surgical Procedures es_ES
dc.subject.meshCase-Control Studies es_ES
dc.subject.meshEuropean Continental Ancestry Group es_ES
dc.subject.meshFemale es_ES
dc.subject.meshGene Frequency es_ES
dc.subject.meshGenotype es_ES
dc.subject.meshHumans es_ES
dc.subject.meshLipopolysaccharide Receptors es_ES
dc.subject.meshMale es_ES
dc.subject.meshMiddle Aged es_ES
dc.subject.meshPolymorphism, Single Nucleotide es_ES
dc.subject.meshRetrospective Studies es_ES
dc.subject.meshRisk Factors es_ES
dc.subject.meshSepsis es_ES
dc.subject.meshShock, Septic es_ES
dc.titleAssociation of CD14 rs2569190 polymorphism with mortality in shock septic patients who underwent major cardiac or abdominal surgery: A retrospective studyes_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID29426837es_ES
dc.format.volume8es_ES
dc.format.number1es_ES
dc.format.page2698es_ES
dc.identifier.doi10.1038/s41598-018-20766-7es_ES
dc.contributor.funderInstituto de Salud Carlos III 
dc.contributor.funderUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) 
dc.contributor.funderJunta de Castilla y León (España) 
dc.description.peerreviewedes_ES
dc.identifier.e-issn2045-2322es_ES
dc.relation.publisherversionhttps://doi.org/10.1038/s41598-018-20766-7es_ES
dc.identifier.journalScientific reportses_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/ PT13/0001es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI15/01451es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/GRS 463/A/10es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/773/A/13es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/CT25-ESP01-01es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/CD13/00013es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/CD14/00002es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/CP14CIII/00010es_ES
dc.rights.accessRightsopen accesses_ES


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Atribución 4.0 Internacional
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