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dc.contributor.author | Abarrategi, Ander | |
dc.contributor.author | Gambera, Stefano | |
dc.contributor.author | Alfranca, Arantzazu | |
dc.contributor.author | Rodriguez-Milla, Miguel A | |
dc.contributor.author | Perez-Tavarez, Raquel | |
dc.contributor.author | Rouault-Pierre, Kevin | |
dc.contributor.author | Waclawiczek, Alexander | |
dc.contributor.author | Chakravarty, Probir | |
dc.contributor.author | Mulero, Francisca | |
dc.contributor.author | Trigueros, César | |
dc.contributor.author | Navarro, Samuel | |
dc.contributor.author | Bonnet, Dominique | |
dc.contributor.author | Garcia-Castro, Javier | |
dc.date.accessioned | 2020-02-21T12:38:06Z | |
dc.date.available | 2020-02-21T12:38:06Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Sci Rep. 2018 Oct 23;8(1):15615. | es_ES |
dc.identifier.issn | 2045-2322 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/9136 | |
dc.description.abstract | Mesenchymal progenitor cells (MPCs) have been hypothesized as cells of origin for sarcomas, and c-Fos transcription factor has been showed to act as an oncogene in bone tumors. In this study, we show c-Fos is present in most sarcomas with chondral phenotype, while multiple other genes are related to c-Fos expression pattern. To further define the role of c-Fos in sarcomagenesis, we expressed it in primary human MPCs (hMPCs), immortalized hMPCs and transformed murine MPCs (mMPCs). In immortalized hMPCs, c-Fos expression generated morphological changes, reduced mobility capacity and impaired adipogenic- and osteogenic-differentiation potentials. Remarkably, immortalized hMPCs or mMPCs expressing c-Fos generated tumors harboring a chondrogenic phenotype and morphology. Thus, here we show that c-Fos protein has a key role in sarcomas and that c-Fos expression in immortalized MPCs yields cell transformation and chondrogenic tumor formation. | es_ES |
dc.description.sponsorship | This work was supported by grants from the Fondo de Investigaciones Sanitarias (FIS: PI11/00377 to J.G.-C.; and RTICC: RD12/0036/0027 to J.G-C, RD12/0036/0020 to S.M.) and the Madrid Regional Government (CellCAM; P2010/BMD-2420 to J.G.-C) in Spain. A.A. was supported by Juan de la Cierva program of the Spanish Plan Nacional (MINECO) and Sara Borrell program of the ISCIII/FEDER. A.Al. was supported by the “Miguel Servet” program of the ISCIII/FEDER. We gratefully acknowledge support from Asociación Pablo Ugarte (CIF G86121019) and AFANION (CIF G02223733). The experiments were approved by the appropriate committees. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Nature Publishing Group | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject.mesh | Animals | es_ES |
dc.subject.mesh | Carcinogenesis | es_ES |
dc.subject.mesh | Cell Line | es_ES |
dc.subject.mesh | Cell Transformation, Neoplastic | es_ES |
dc.subject.mesh | Gene Expression Regulation, Neoplastic | es_ES |
dc.subject.mesh | Genes, fos | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Mesenchymal Stem Cells | es_ES |
dc.subject.mesh | Mice | es_ES |
dc.subject.mesh | Mice, Inbred NOD | es_ES |
dc.subject.mesh | Mice, SCID | es_ES |
dc.subject.mesh | Proto-Oncogene Proteins c-fos | es_ES |
dc.subject.mesh | Sarcoma | es_ES |
dc.title | c-Fos induces chondrogenic tumor formation in immortalized human mesenchymal progenitor cells | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 30353072 | es_ES |
dc.format.volume | 8 | es_ES |
dc.format.number | 1 | es_ES |
dc.format.page | 15615 | es_ES |
dc.identifier.doi | 10.1038/s41598-018-33689-0 | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.contributor.funder | Comunidad de Madrid (España) | |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 2045-2322 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1038/s41598-018-33689-0 | es_ES |
dc.identifier.journal | Scientific reports | es_ES |
dc.repisalud.centro | ISCIII::Instituto de Investigación de Enfermedades Raras | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI11/00377 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/RD12/0036/0027 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/RD12/0036/0020 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/P2010/BMD-2420 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/ | es_ES |
dc.rights.accessRights | open access | es_ES |