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dc.contributor.authorAbarrategi, Ander 
dc.contributor.authorGambera, Stefano 
dc.contributor.authorAlfranca, Arantzazu 
dc.contributor.authorRodriguez-Milla, Miguel A 
dc.contributor.authorPerez-Tavarez, Raquel 
dc.contributor.authorRouault-Pierre, Kevin
dc.contributor.authorWaclawiczek, Alexander
dc.contributor.authorChakravarty, Probir
dc.contributor.authorMulero, Francisca 
dc.contributor.authorTrigueros, César
dc.contributor.authorNavarro, Samuel
dc.contributor.authorBonnet, Dominique
dc.contributor.authorGarcia-Castro, Javier 
dc.date.accessioned2020-02-21T12:38:06Z
dc.date.available2020-02-21T12:38:06Z
dc.date.issued2018
dc.identifier.citationSci Rep. 2018 Oct 23;8(1):15615.es_ES
dc.identifier.issn2045-2322es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/9136
dc.description.abstractMesenchymal progenitor cells (MPCs) have been hypothesized as cells of origin for sarcomas, and c-Fos transcription factor has been showed to act as an oncogene in bone tumors. In this study, we show c-Fos is present in most sarcomas with chondral phenotype, while multiple other genes are related to c-Fos expression pattern. To further define the role of c-Fos in sarcomagenesis, we expressed it in primary human MPCs (hMPCs), immortalized hMPCs and transformed murine MPCs (mMPCs). In immortalized hMPCs, c-Fos expression generated morphological changes, reduced mobility capacity and impaired adipogenic- and osteogenic-differentiation potentials. Remarkably, immortalized hMPCs or mMPCs expressing c-Fos generated tumors harboring a chondrogenic phenotype and morphology. Thus, here we show that c-Fos protein has a key role in sarcomas and that c-Fos expression in immortalized MPCs yields cell transformation and chondrogenic tumor formation.es_ES
dc.description.sponsorshipThis work was supported by grants from the Fondo de Investigaciones Sanitarias (FIS: PI11/00377 to J.G.-C.; and RTICC: RD12/0036/0027 to J.G-C, RD12/0036/0020 to S.M.) and the Madrid Regional Government (CellCAM; P2010/BMD-2420 to J.G.-C) in Spain. A.A. was supported by Juan de la Cierva program of the Spanish Plan Nacional (MINECO) and Sara Borrell program of the ISCIII/FEDER. A.Al. was supported by the “Miguel Servet” program of the ISCIII/FEDER. We gratefully acknowledge support from Asociación Pablo Ugarte (CIF G86121019) and AFANION (CIF G02223733). The experiments were approved by the appropriate committees.es_ES
dc.language.isoenges_ES
dc.publisherNature Publishing Group es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.meshAnimals es_ES
dc.subject.meshCarcinogenesis es_ES
dc.subject.meshCell Line es_ES
dc.subject.meshCell Transformation, Neoplastices_ES
dc.subject.meshGene Expression Regulation, Neoplastic es_ES
dc.subject.meshGenes, fos es_ES
dc.subject.meshHumans es_ES
dc.subject.meshMesenchymal Stem Cells es_ES
dc.subject.meshMice es_ES
dc.subject.meshMice, Inbred NOD es_ES
dc.subject.meshMice, SCID es_ES
dc.subject.meshProto-Oncogene Proteins c-fos es_ES
dc.subject.meshSarcoma es_ES
dc.titlec-Fos induces chondrogenic tumor formation in immortalized human mesenchymal progenitor cellses_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID30353072es_ES
dc.format.volume8es_ES
dc.format.number1es_ES
dc.format.page15615es_ES
dc.identifier.doi10.1038/s41598-018-33689-0es_ES
dc.contributor.funderInstituto de Salud Carlos III 
dc.contributor.funderComunidad de Madrid (España) 
dc.contributor.funderMinisterio de Economía y Competitividad (España) 
dc.contributor.funderUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) 
dc.description.peerreviewedes_ES
dc.identifier.e-issn2045-2322es_ES
dc.relation.publisherversionhttps://doi.org/10.1038/s41598-018-33689-0es_ES
dc.identifier.journalScientific reportses_ES
dc.repisalud.centroISCIII::Instituto de Investigación de Enfermedades Rarases_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI11/00377es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/RD12/0036/0027es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/RD12/0036/0020es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/P2010/BMD-2420es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/es_ES
dc.rights.accessRightsopen accesses_ES


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Atribución 4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Atribución 4.0 Internacional