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dc.contributor.authorZaragoza, Oscar 
dc.date.accessioned2020-02-21T10:58:41Z
dc.date.available2020-02-21T10:58:41Z
dc.date.issued2011
dc.identifier.citationFront Microbiol. 2011 Sep 6;2:181.es_ES
dc.identifier.issn1664-302Xes_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/9135
dc.description.abstractAlthough morphological transitions (such as hyphae and pseudohyphae formation) are a common feature among fungi, the encapsulated pathogenic yeast Cryptococcus neoformans is found during infection as blastoconidia. However, this fungus exhibits striking variations in cellular structure and size, which have important consequences during infection. This review will summarize the main aspects related with phenotypic and morphological variations in C. neoformans, which can be divided in three classes. Two of them are related to changes in the capsule, while the third one involves changes in the whole cell. The three morphological and phenotypic variations in C. neoformans can be classified as: (1) changes in capsule structure, (2) changes in capsule size, and (3) changes in the total size of the cell, which can be achieved by the formation of cryptococcal giant/titan cells or microforms. These changes have profound consequences on the interaction with the host, involving survival, phagocytosis escape and immune evasion and dissemination. This article will summarize the main features of these changes, and highlight their importance during the interaction with the host and how they contribute to the development of the disease.es_ES
dc.description.sponsorshipI warmly thank my colleague and friend Helene Eisenman for her careful critical reading of the manuscript and for her helpful suggestions. Oscar Zaragoza is funded by grant SAF2008-03761 from the Spanish Ministry of Science and Innovation.es_ES
dc.language.isoenges_ES
dc.publisherFrontiers Mediaes_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectCryptococcus neoformanses_ES
dc.subjectantigenic variationses_ES
dc.subjectcapsule enlargementes_ES
dc.subjectgiant cellses_ES
dc.subjectmicro-cellses_ES
dc.subjectmorphogenesises_ES
dc.titleMultiple Disguises for the Same Party: The Concepts of Morphogenesis and Phenotypic Variations in Cryptococcus neoformanses_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.identifier.pubmedID21922016es_ES
dc.format.volume2es_ES
dc.format.page181es_ES
dc.identifier.doi10.3389/fmicb.2011.00181es_ES
dc.contributor.funderMinisterio de Ciencia e Innovación (España)
dc.description.peerreviewedes_ES
dc.identifier.e-issn1664-302Xes_ES
dc.relation.publisherversionhttps://doi.org/10.3389/fmicb.2011.00181es_ES
dc.identifier.journalFrontiers in microbiologyes_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2008-03761es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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Atribución-NoComercial-CompartirIgual 4.0 Internacional
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