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dc.contributor.authorMesa-Arango, Ana C 
dc.contributor.authorScorzoni, Liliana 
dc.contributor.authorZaragoza, Oscar 
dc.date.accessioned2020-02-21T10:58:18Z
dc.date.available2020-02-21T10:58:18Z
dc.date.issued2012
dc.identifier.citationFront Microbiol. 2012 Aug 8;3:286. eCollectiones_ES
dc.identifier.issn1664-302Xes_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/9133
dc.description.abstract"Amphotericin B acts through pore formation at the cell membrane after binding to ergosterol" is an accepted dogma about the action mechanism of this antifungal, and this sentence is widely found in the literature. But after 60 years of investigation, the action mechanism of Amphotericin B is not fully elucidated. Amphotericin B is a polyene substance that is one of the most effective drugs for the treatment of fungal and parasite infections. As stated above, the first mechanism of action described was pore formation after binding to the ergosterol present in the membrane. But it has also been demonstrated that AmB induces oxidative damage in the cells. Moreover, amphotericin B modulates the immune system, and this activity has been related to the protective effect of the molecule, but also to its toxicity in the host. This review tries to provide a general overview of the main aspects of this molecule, and highlight the multiple effects that this molecule has on both the fungal and host cells.es_ES
dc.description.sponsorshipAna C. Mesa-Arango is funded by a grant from Fundación Carolina and University of Antioquia, Medellin, Colombia, and Liliana Scorzoni is supported by fellowship from the Agencia Española de Cooperación Internacional para el Desarrollo. Oscar Zaragoza is funded by grant SAF2011-25140 from the Spanish Ministry for Economics and Competitivity.es_ES
dc.language.isoenges_ES
dc.publisherFrontiers Mediaes_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectamphotericin Bes_ES
dc.subjectfungal infectiones_ES
dc.subjectimmunomodulationes_ES
dc.subjectoxidative damagees_ES
dc.subjectporees_ES
dc.titleIt only takes one to do many jobs: Amphotericin B as antifungal and immunomodulatory druges_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID23024638es_ES
dc.format.volume3es_ES
dc.format.page286es_ES
dc.identifier.doi10.3389/fmicb.2012.00286es_ES
dc.contributor.funderFundación Carolina
dc.contributor.funderAgencia Española de Cooperación Internacional para el Desarrollo
dc.contributor.funderMinisterio de Economía y Competitividad (España)
dc.description.peerreviewedes_ES
dc.identifier.e-issn1664-302Xes_ES
dc.relation.publisherversionhttps://doi.org/10.3389/fmicb.2012.00286es_ES
dc.identifier.journalFrontiers in microbiologyes_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2011-25140es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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