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dc.contributor.authorSguassero, Yanina
dc.contributor.authorRoberts, Karen N
dc.contributor.authorHarvey, Guillermina B
dc.contributor.authorComandé, Daniel
dc.contributor.authorCiapponi, Agustín
dc.contributor.authorCuesta, Cristina B
dc.contributor.authorAguiar, Camila
dc.contributor.authorCastro, Ana M de
dc.contributor.authorDanesi, Emmaría
dc.contributor.authorde Andrade, Ana L
dc.contributor.authorde Lana, Marta
dc.contributor.authorEscribà, Josep M
dc.contributor.authorFabbro, Diana L
dc.contributor.authorFernandes, Cloé D
dc.contributor.authorFlores-Chavez, Maria 
dc.contributor.authorHasslocher-Moreno, Alejandro M
dc.contributor.authorJackson, Yves
dc.contributor.authorLacunza, Carlos D
dc.contributor.authorMachado-de-Assis, Girley F
dc.contributor.authorMaldonado, Marisel
dc.contributor.authorMeira, Wendell S F
dc.contributor.authorMolina, Israel
dc.contributor.authorMonje-Rumi, María M
dc.contributor.authorMuñoz-San Martín, Catalina
dc.contributor.authorMurcia, Laura
dc.contributor.authorNery de Castro, Cleudson
dc.contributor.authorSánchez Negrette, Olga
dc.contributor.authorSegovia, Manuel
dc.contributor.authorSilveira, Celeste A N
dc.contributor.authorSolari, Aldo
dc.contributor.authorSteindel, Mário
dc.contributor.authorStreiger, Mirtha L
dc.contributor.authorVera de Bilbao, Ninfa
dc.contributor.authorZulantay, Inés
dc.contributor.authorSosa-Estani, Sergio
dc.identifier.citationInt J Infect Dis. 2018 Aug;73:93-101.es_ES
dc.description.abstractOBJECTIVE: To determine the course of serological tests in subjects with chronic Trypanosoma cruzi infection treated with anti-trypanosomal drugs. METHODS: A systematic review and meta-analysis was conducted using individual participant data. Survival analysis and the Cox proportional hazards regression model with random effects to adjust for covariates were applied. The protocol was registered in the PROSPERO database (; CRD42012002162). RESULTS: A total of 27 studies (1296 subjects) conducted in eight countries were included. The risk of bias was low for all domains in 17 studies (63.0%). Nine hundred and thirteen subjects were assessed (149 seroreversion events, 83.7% censored data) for enzyme-linked immunosorbent assay (ELISA), 670 subjects (134 events, 80.0% censored) for indirect immunofluorescence assay (IIF), and 548 subjects (99 events, 82.0% censored) for indirect hemagglutination assay (IHA). A higher probability of seroreversion was observed within a shorter time span in subjects aged 1-19 years compared to adults. The chance of seroreversion also varied according to the country where the infection might have been acquired. For instance, the pooled adjusted hazard ratio between children/adolescents and adults for the IIF test was 1.54 (95% confidence interval 0.64-3.71) for certain countries of South America (Argentina, Bolivia, Chile, and Paraguay) and 9.37 (95% confidence interval 3.44-25.50) for Brazil. CONCLUSIONS: The disappearance of anti-T. cruzi antibodies was demonstrated along the course of follow-up. An interaction between age at treatment and country setting was found.es_ES
dc.description.sponsorshipYS was granted a UNDP/UNFPA/UNICEF/WHO/World Bank Special Programme for Research and Training in Tropical Diseases (TDR), World Health Organization, Geneva, Switzerland (grant number B20393). This article was supported by the European project BERENICE, a collaborative project which is funded under the European Community’s 7th Framework Programme (grant agreement number: HEALTH-30593). Each of the authors was supported by their individual institutions. The views expressed are those of the authors and are not necessarily those of the WHO or any of the institutions with which the authors are affiliated.es_ES
dc.relation.isversionofPublisher's versiones_ES
dc.subjectChronic diseasees_ES
dc.subjectFollow-up studieses_ES
dc.subjectIndividual participant dataes_ES
dc.subjectSerologic testses_ES
dc.subjectTrypanosoma cruzies_ES
dc.subject.meshAdolescent es_ES
dc.subject.meshAdult es_ES
dc.subject.meshAntibodies, Protozoan es_ES
dc.subject.meshChagas Disease es_ES
dc.subject.meshChild es_ES
dc.subject.meshChild, Preschool es_ES
dc.subject.meshChronic Disease es_ES
dc.subject.meshEnzyme-Linked Immunosorbent Assay es_ES
dc.subject.meshFemale es_ES
dc.subject.meshFluorescent Antibody Technique, Indirect es_ES
dc.subject.meshHemagglutination Tests es_ES
dc.subject.meshHumans es_ES
dc.subject.meshInfant es_ES
dc.subject.meshMale es_ES
dc.subject.meshSerologic Tests es_ES
dc.subject.meshYoung Adult es_ES
dc.titleCourse of serological tests in treated subjects with chronic Trypanosoma cruzi infection: A systematic review and meta-analysis of individual participant dataes_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.contributor.funderEuropean Uniones_ES
dc.contributor.funderWorld Health Organization (WHO)es_ES
dc.identifier.journalInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseaseses_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES

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Atribución-NoComercial-CompartirIgual 4.0 Internacional
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