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dc.contributor.authorChicharro, Carmen 
dc.contributor.authorLlanes-Acevedo, Ivonne Pamela 
dc.contributor.authorGarcia, Emilia 
dc.contributor.authorNieto Martinez, Francisco Javier 
dc.contributor.authorMoreno, Javier 
dc.contributor.authorCruz, Israel 
dc.date.accessioned2020-02-03T08:59:09Z
dc.date.available2020-02-03T08:59:09Z
dc.date.issued2013-07-25
dc.identifier.citationEuro Surveill. 2013 Jul 25;18(30):20545.es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/9006
dc.description.abstractLeishmaniasis is endemic in south-west Europe. Recent data point to the spread and (re-)emergence of this disease in previously endemic and non-endemic European countries. A recent example is the urban community outbreak of cutaneous and visceral leishmaniasis in the south-west of Madrid autonomous community, Spain, which began on 1 July 2009. A total of 446 cases associated to this outbreak were reported up to 31 December 2012. We show molecular typing data for 73 Leishmania infantum isolates obtained from January 2008 to July 2012 from different areas of Madrid, including those affected by the outbreak. Seven different genotypes were identified by combining data from two targets: the ribosomal internal transcribed spacers (ITS)-1 and -2 and the haspb (k26) gene. The results contribute to a better understanding of the parasite population circulating in the region, and indicate that most of the outbreak-associated isolates (22/31) were infected by parasites with the same combined genotype. Additional data from 82 L. infantum isolates typed as either MON-1 or MON-24 by isoenzyme analysis indicate that far from concluding that the outbreak was caused by a 'new' emerging genotype, further molecular typing-based surveillance studies are required to better understand the epidemiology of leishmaniasis in the region.es_ES
dc.description.sponsorshipThis study was supported in part by Instituto de Salud Carlos III (Grant number MPY-1248/12). Ivonne Pamela Llanes Acevedo is granted by Fundación para el Futuro de Colombia, COLFUTURO).es_ES
dc.language.isoenges_ES
dc.publisherEuropean Centre for Disease Prevention and Control (ECDC) es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.meshAdolescent es_ES
dc.subject.meshAdult es_ES
dc.subject.meshAged es_ES
dc.subject.meshFemale es_ES
dc.subject.meshGenotype es_ES
dc.subject.meshHumans es_ES
dc.subject.meshLeishmania infantum es_ES
dc.subject.meshLeishmaniasis, Visceral es_ES
dc.subject.meshMale es_ES
dc.subject.meshMiddle Aged es_ES
dc.subject.meshMolecular Typing es_ES
dc.subject.meshPhylogeny es_ES
dc.subject.meshSpain es_ES
dc.subject.meshYoung Adult es_ES
dc.subject.meshDisease Outbreaks es_ES
dc.titleMolecular typing of Leishmania infantum isolates from a leishmaniasis outbreak in Madrid, Spain, 2009 to 2012es_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID23929179es_ES
dc.format.volume18es_ES
dc.format.number30es_ES
dc.format.page20545es_ES
dc.identifier.doi10.2807/1560-7917.es2013.18.30.20545es_ES
dc.contributor.funderInstituto de Salud Carlos III 
dc.description.peerreviewedes_ES
dc.identifier.e-issn1560-7917es_ES
dc.relation.publisherversionhttps://doi.org/10.2807/1560-7917.es2013.18.30.20545es_ES
dc.identifier.journalEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletines_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/MPY-1248/12)es_ES
dc.rights.accessRightsopen accesses_ES


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Atribución 4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Atribución 4.0 Internacional