Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/8995
2015/16 seasonal vaccine effectiveness against hospitalisation with influenza A(H1N1)pdm09 and B among elderly people in Europe: results from the I-MOVE+ project
Rondy, Marc | Larrauri, Amparo ISCIII | Casado, Itziar | Alfonsi, Valeria | Pitigoi, Daniela | Launay, Odile | Syrjänen, Ritva K | Gefenaite, Giedre | Machado, Ausenda | Vučina, Vesna Višekruna | Horváth, Judith Krisztina | Paradowska-Stankiewicz, Iwona | Marbus, Sierk D | Gherasim, Alin ISCIII | Díaz-González, Jorge Alberto | Rizzo, Caterina | Ivanciuc, Alina E | Galtier, Florence | Ikonen, Niina | Mickiene, Aukse | Gomez, Veronica | Kurečić Filipović, Sanja | Ferenczi, Annamária | Korcinska, Monika R | van Gageldonk-Lafeber, Rianne | Valenciano, Marta
Euro Surveill. 2017 Jul 27;22(30). pii: 30580.
We conducted a multicentre test-negative case-control study in 27 hospitals of 11 European countries to measure 2015/16 influenza vaccine effectiveness (IVE) against hospitalised influenza A(H1N1)pdm09 and B among people aged ≥ 65 years. Patients swabbed within 7 days after onset of symptoms compatible with severe acute respiratory infection were included. Information on demographics, vaccination and underlying conditions was collected. Using logistic regression, we measured IVE adjusted for potential confounders. We included 355 influenza A(H1N1)pdm09 cases, 110 influenza B cases, and 1,274 controls. Adjusted IVE against influenza A(H1N1)pdm09 was 42% (95% confidence interval (CI): 22 to 57). It was 59% (95% CI: 23 to 78), 48% (95% CI: 5 to 71), 43% (95% CI: 8 to 65) and 39% (95% CI: 7 to 60) in patients with diabetes mellitus, cancer, lung and heart disease, respectively. Adjusted IVE against influenza B was 52% (95% CI: 24 to 70). It was 62% (95% CI: 5 to 85), 60% (95% CI: 18 to 80) and 36% (95% CI: -23 to 67) in patients with diabetes mellitus, lung and heart disease, respectively. 2015/16 IVE estimates against hospitalised influenza in elderly people was moderate against influenza A(H1N1)pdm09 and B, including among those with diabetes mellitus, cancer, lung or heart diseases.
case control | elderly | hospitalisation | influenza | severe acute respiratory infection | vaccine effectiveness | vaccine-preventable diseases
Aged | Aged, 80 and over | Europe | Female | Hospitalization | Humans | Influenza A Virus, H1N1 Subtype | Influenza B virus | Influenza Vaccines | Influenza, Human | Logistic Models | Male | Outcome Assessment, Health Care | Seasons | Sentinel Surveillance | Vaccination | Vaccine Potency
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