dc.contributor.author | Ramirez de Arellano, Eva | |
dc.contributor.author | Sanchez-Lockhart, Mariano | |
dc.contributor.author | Perteguer-Prieto, Maria Jesus | |
dc.contributor.author | Bartlett, Maggie | |
dc.contributor.author | Ortiz Rivera, Marta | |
dc.contributor.author | Campioli, Pamela | |
dc.contributor.author | Hernandez-Gonzalez, Ana | |
dc.contributor.author | Gonzalez, Jeanette | |
dc.contributor.author | Garcia, Karla | |
dc.contributor.author | Ramos, Manuel | |
dc.contributor.author | Jiménez-Clavero, Miguel Ángel | |
dc.contributor.author | Tenorio, Antonio | |
dc.contributor.author | Sánchez-Seco, María Paz | |
dc.contributor.author | González, Félix | |
dc.contributor.author | Echevarria, Juan Emilio | |
dc.contributor.author | Palacios, Gustavo | |
dc.contributor.author | Negredo, Anabel | |
dc.date.accessioned | 2020-01-29T11:46:47Z | |
dc.date.available | 2020-01-29T11:46:47Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Viruses. 2019 Apr 19;11(4). pii: E360. | es_ES |
dc.identifier.issn | 1999-4915 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/8970 | |
dc.description.abstract | Although Lloviu virus (LLOV) was discovered in the carcasses of insectivorous Schreiber's Bent-winged bats in the caves of Northern Spain in 2002, its infectivity and pathogenicity remain unclear. We examined the seroprevalence of LLOV in potentially exposed Schreiber's Bent-winged bats (n = 60), common serotine bats (n = 10) as controls, and humans (n = 22) using an immunoblot assay. We found antibodies against LLOV GP2 in all of Schreiber's Bent-winged bats serum pools, but not in any of the common serotine bats and human pools tested. To confirm this seroreactivity, 52 serums were individually tested using Domain Programmable Arrays (DPA), a phage display based-system serology technique for profiling filovirus epitopes. A serological signature against different LLOV proteins was obtained in 19/52 samples tested (36.5%). The immunodominant response was in the majority specific to LLOV-unique epitopes, confirming that the serological response detected was to LLOV. To our knowledge, this is the first serological evidence of LLOV exposure in live captured Schreiber's Bent-winged bats, dissociating LLOV circulation as the cause of the previously reported die-offs. | es_ES |
dc.description.sponsorship | This work was conducted at the facilities of the ISCIII and financially supported by the project VIROBAT3 (SAF2013-47194-P) of the General Research Program of the Spanish, projects RD12/0018/0006, RD12/0018/0011 and RD16CIII/0003/0003, RD16CIII/0003/0004, from RICET (Red de Enfermedades Tropicales), Subprogram RETICS Plan Estatal de I D I 2013-2016, and co-funded by FEDER “A way to do Europe”. The first author of this study was contracted by Sara Borrell program funded by FIS (Fondo de Investigación Sanitaria) with expedient number CD10/00009 -MPY1434/10. The analyses done by Maggie Bartlett is supported by work funded by the National Science Foundation under Grant No. (1757346). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Bats | es_ES |
dc.subject | Human | es_ES |
dc.subject | Lloviu virus | es_ES |
dc.subject | Prevalence | es_ES |
dc.subject | Serology | es_ES |
dc.title | First Evidence of Antibodies Against Lloviu Virus in Schreiber's Bent-Winged Insectivorous Bats Demonstrate a Wide Circulation of the Virus in Spain | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 31010201 | es_ES |
dc.format.volume | 11 | es_ES |
dc.format.number | 4 | es_ES |
dc.format.page | 360 | es_ES |
dc.identifier.doi | Viruses. 2019 Apr 19;11(4). pii: E360. | es_ES |
dc.contributor.funder | RETICS-Investigación colaborativa en Enfermedades Tropicales (RICET-ISCIII) (España) | |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.contributor.funder | National Science Foundation (Estados Unidos) | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1999-4915 | es_ES |
dc.relation.publisherversion | https://doi.org/Viruses. 2019 Apr 19;11(4). pii: E360. | es_ES |
dc.identifier.journal | Viruses | es_ES |
dc.repisalud.centro | ISCIII::Centro Nacional de Microbiología | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/VIROBAT3 SAF2013-47194-P | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/RD12/0018/0006 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/RD12/0018/0011 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/RD16CIII/0003/0003 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/RD16CIII/0003/0004 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/CD10/00009-MPY1434/10 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/1757346 | es_ES |
dc.rights.accessRights | open access | es_ES |