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dc.contributor.authorRamírez de Arellano, Eva 
dc.contributor.authorSanchez-Lockhart, Mariano
dc.contributor.authorPerteguer-Prieto, Maria Jesus 
dc.contributor.authorBartlett, Maggie
dc.contributor.authorOrtiz-Rivera, Marta 
dc.contributor.authorCampioli, Pamela 
dc.contributor.authorHernández-González, Ana 
dc.contributor.authorGonzalez, Jeanette
dc.contributor.authorGarcia, Karla
dc.contributor.authorCeron, Carlos 
dc.contributor.authorJiménez-Clavero, Miguel Ángel
dc.contributor.authorTenorio, Antonio 
dc.contributor.authorSanchez-Seco, Paz 
dc.contributor.authorGonzález, Félix
dc.contributor.authorEchevarria, Juan Emilio 
dc.contributor.authorPalacios, Gustavo
dc.contributor.authorNegredo, Anabel 
dc.date.accessioned2020-01-29T11:46:47Z
dc.date.available2020-01-29T11:46:47Z
dc.date.issued2019
dc.identifier.citationViruses. 2019 Apr 19;11(4). pii: E360.es_ES
dc.identifier.issn1999-4915es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/8970
dc.description.abstractAlthough Lloviu virus (LLOV) was discovered in the carcasses of insectivorous Schreiber's Bent-winged bats in the caves of Northern Spain in 2002, its infectivity and pathogenicity remain unclear. We examined the seroprevalence of LLOV in potentially exposed Schreiber's Bent-winged bats (n = 60), common serotine bats (n = 10) as controls, and humans (n = 22) using an immunoblot assay. We found antibodies against LLOV GP2 in all of Schreiber's Bent-winged bats serum pools, but not in any of the common serotine bats and human pools tested. To confirm this seroreactivity, 52 serums were individually tested using Domain Programmable Arrays (DPA), a phage display based-system serology technique for profiling filovirus epitopes. A serological signature against different LLOV proteins was obtained in 19/52 samples tested (36.5%). The immunodominant response was in the majority specific to LLOV-unique epitopes, confirming that the serological response detected was to LLOV. To our knowledge, this is the first serological evidence of LLOV exposure in live captured Schreiber's Bent-winged bats, dissociating LLOV circulation as the cause of the previously reported die-offs.es_ES
dc.description.sponsorshipThis work was conducted at the facilities of the ISCIII and financially supported by the project VIROBAT3 (SAF2013-47194-P) of the General Research Program of the Spanish, projects RD12/0018/0006, RD12/0018/0011 and RD16CIII/0003/0003, RD16CIII/0003/0004, from RICET (Red de Enfermedades Tropicales), Subprogram RETICS Plan Estatal de I D I 2013-2016, and co-funded by FEDER “A way to do Europe”. The first author of this study was contracted by Sara Borrell program funded by FIS (Fondo de Investigación Sanitaria) with expedient number CD10/00009 -MPY1434/10. The analyses done by Maggie Bartlett is supported by work funded by the National Science Foundation under Grant No. (1757346).es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectBatses_ES
dc.subjectHumanes_ES
dc.subjectLloviu viruses_ES
dc.subjectPrevalencees_ES
dc.subjectSerologyes_ES
dc.titleFirst Evidence of Antibodies Against Lloviu Virus in Schreiber's Bent-Winged Insectivorous Bats Demonstrate a Wide Circulation of the Virus in Spaines_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID31010201es_ES
dc.format.volume11es_ES
dc.format.number4es_ES
dc.format.page360es_ES
dc.identifier.doiViruses. 2019 Apr 19;11(4). pii: E360.es_ES
dc.contributor.funderRed de Investigación Cooperativa en Enfermedades Tropicales (España)es_ES
dc.contributor.funderEuropean Regional Development Fund (ERDF/FEDER)es_ES
dc.contributor.funderFondo de Investigaciones Sanitariases_ES
dc.contributor.funderNational Science Foundation (United States)es_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn1999-4915es_ES
dc.relation.publisherversionhttps://doi.org/Viruses. 2019 Apr 19;11(4). pii: E360.es_ES
dc.identifier.journalViruseses_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/VIROBAT3 SAF2013-47194-Pes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/RD12/0018/0006es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/RD12/0018/0011es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/RD16CIII/0003/0003es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/RD16CIII/0003/0004es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/CD10/00009-MPY1434/10es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/1757346es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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