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dc.contributor.authorRivero-Menendez, Olga 
dc.contributor.authorAlastruey-Izquierdo, Ana 
dc.contributor.authorMellado, Emilia 
dc.contributor.authorCuenca-Estrella, Manuel 
dc.date.accessioned2020-01-29T11:45:42Z
dc.date.available2020-01-29T11:45:42Z
dc.date.issued2016-07-04
dc.identifier.citationJ Fungi (Basel). 2016 Jul 4;2(3). pii: E21.es_ES
dc.identifier.issn2309-608Xes_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/8967
dc.description.abstractSince the first description of an azole-resistant A. fumigatus strain in 1997, there has been an increasing number of papers describing the emergence of azole resistance. Firstly reported in the USA and soon after in Europe, it has now been described worldwide, challenging the management of human aspergillosis. The main mechanism of resistance is the modification of the azole target enzyme: 14-α sterol demethylase, encoded by the cyp51A gene; although recently, other resistance mechanisms have also been implicated. In addition, a shift in the epidemiology has been noted with other Aspergillus species (mostly azole resistant) increasingly being reported as causative agents of human disease. This paper reviews the current situation of Aspergillus azole resistance and its implications in the clinical setting.es_ES
dc.description.sponsorshipThe research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Olga Rivero-Menendez holds a predoctoral fellowship from the Fondo de Investigaciones Sanitarias (FI14CIII/00025).es_ES
dc.language.isoenges_ES
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI) es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectAspergillus fumigatuses_ES
dc.subjectAspergillosises_ES
dc.subjectAzole drug resistancees_ES
dc.subjectcyp51Aes_ES
dc.subjectMutationses_ES
dc.titleTriazole Resistance in Aspergillus spp.: A Worldwide Problem?es_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID29376938es_ES
dc.format.volume2es_ES
dc.format.number3es_ES
dc.format.page21es_ES
dc.identifier.doi10.3390/jof2030021es_ES
dc.contributor.funderInstituto de Salud Carlos III 
dc.description.peerreviewedes_ES
dc.identifier.e-issn2309-608Xes_ES
dc.relation.publisherversionhttps://doi.org/10.3390/jof2030021es_ES
dc.identifier.journalJournal of fungi (Basel, Switzerland)es_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/FI14CIII/00025es_ES
dc.rights.accessRightsopen accesses_ES


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Atribución 4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Atribución 4.0 Internacional