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dc.contributor.author | Rivero-Menendez, Olga | |
dc.contributor.author | Alastruey-Izquierdo, Ana | |
dc.contributor.author | Mellado, Emilia | |
dc.contributor.author | Cuenca-Estrella, Manuel | |
dc.date.accessioned | 2020-01-29T11:45:42Z | |
dc.date.available | 2020-01-29T11:45:42Z | |
dc.date.issued | 2016-07-04 | |
dc.identifier.citation | J Fungi (Basel). 2016 Jul 4;2(3). pii: E21. | es_ES |
dc.identifier.issn | 2309-608X | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/8967 | |
dc.description.abstract | Since the first description of an azole-resistant A. fumigatus strain in 1997, there has been an increasing number of papers describing the emergence of azole resistance. Firstly reported in the USA and soon after in Europe, it has now been described worldwide, challenging the management of human aspergillosis. The main mechanism of resistance is the modification of the azole target enzyme: 14-α sterol demethylase, encoded by the cyp51A gene; although recently, other resistance mechanisms have also been implicated. In addition, a shift in the epidemiology has been noted with other Aspergillus species (mostly azole resistant) increasingly being reported as causative agents of human disease. This paper reviews the current situation of Aspergillus azole resistance and its implications in the clinical setting. | es_ES |
dc.description.sponsorship | The research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Olga Rivero-Menendez holds a predoctoral fellowship from the Fondo de Investigaciones Sanitarias (FI14CIII/00025). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Aspergillus fumigatus | es_ES |
dc.subject | Aspergillosis | es_ES |
dc.subject | Azole drug resistance | es_ES |
dc.subject | cyp51A | es_ES |
dc.subject | Mutations | es_ES |
dc.title | Triazole Resistance in Aspergillus spp.: A Worldwide Problem? | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 29376938 | es_ES |
dc.format.volume | 2 | es_ES |
dc.format.number | 3 | es_ES |
dc.format.page | 21 | es_ES |
dc.identifier.doi | 10.3390/jof2030021 | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 2309-608X | es_ES |
dc.relation.publisherversion | https://doi.org/10.3390/jof2030021 | es_ES |
dc.identifier.journal | Journal of fungi (Basel, Switzerland) | es_ES |
dc.repisalud.centro | ISCIII::Centro Nacional de Microbiología | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/FI14CIII/00025 | es_ES |
dc.rights.accessRights | open access | es_ES |