Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/8941
Título
Long-term exposure to trihalomethanes in drinking water and breast cancer in the Spanish multicase-control study on cancer (MCC-SPAIN)
Autor(es)
Font-Ribera, Laia | Gràcia-Lavedan, Esther | Aragones, Nuria ISCIII | Perez-Gomez, Beatriz ISCIII | Pollan-Santamaria, Marina ISCIII | Amiano, Pilar | Jiménez-Zabala, Ana | Castaño-Vinyals, Gemma | Roca-Barceló, Aina | Ardanaz, Eva | Burgui, Rosana | Molina, Antonio José | Fernández-Villa, Tania | Gómez-Acebo, Inés | Dierssen-Sotos, Trinidad | Moreno, Victor | Fernández-Tardón, Guillermo | Peiró, Rosana | Kogevinas, Manolis | Villanueva, Cristina M
Fecha de publicación
2018
Cita
Environ Int. 2018 Mar;112:227-234.
Idioma
Inglés
Tipo de documento
journal article
Resumen
BACKGROUND: Exposure to trihalomethanes (THMs) in drinking water has consistently been associated with an increased risk of bladder cancer, but evidence on other cancers including the breast is very limited. OBJECTIVES: We assessed long-term exposure to THMs to evaluate the association with female breast cancer (BC) risk. METHODS: A multi case-control study was conducted in Spain from 2008 to 2013. We included 1003 incident BC cases (women 20-85years old) recruited from 14 hospitals and 1458 population controls. Subjects were interviewed to ascertain residential histories and major recognized risk factors for BC. Mean residential levels of chloroform, brominated THMs (Br-THMs) and the sum of both as total THM (TTHMs) during the adult-lifetime were calculated. RESULTS: Mean adult-lifetime residential levels ranged from 0.8 to 145.7μg/L for TTHM (median=30.8), from 0.2 to 62.4μg/L for chloroform (median=19.7) and from 0.3 to 126.0μg/L for Br-THMs (median=9.7). Adult-lifetime residential chloroform was associated with BC (adjusted OR=1.47; 95%CI=1.05, 2.06 for the highest (>24μg/L) vs. lowest (<8μg/L) quartile; p-trend=0.024). No association was detected for residential Br-THMs (OR=0.91; 95%CI=0.68, 1.23 for >31μg/L vs. <6μg/L) or TTHMs (OR=1.14; 95%CI=0.83, 1.57 for >48μg/L vs. <22μg/L). CONCLUSIONS: At common levels in Europe, long-term residential total THMs were not related to female breast cancer. A moderate association with chloroform was suggested at the highest exposure category. This large epidemiological study with extensive exposure assessment overcomes several limitations of previous studies but further studies are needed to confirm these results.
Palabras clave
MESH
Adult | Aged | Aged, 80 and over | Breast Neoplasms | Case-Control Studies | Drinking Water | Environmental Exposure | Female | Humans | Middle Aged | Spain | Trihalomethanes | Water Pollutants, Chemical | Young Adult
Versión en línea
DOI
Aparece en las colecciones
- Investigación > IIS > IMIM - Hospital del Mar Research Institute-Barcelona (Cataluña)
- Investigación > IIS > IIS BioGipuzkoa - Asociación Instituto de Investigación Sanitaria BioGipuzkoa (País Vasco)
- Investigación > IIS > IDIBELL - Instituto de Investigación Biomédica de Bellvitge (Cataluña)
- Investigación > ISCIII > Centro Nacional de Epidemiología (CNE) > ISCIII - Artículos