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dc.contributor.authorGutiérrez-González, Enrique 
dc.contributor.authorCastello, Adela 
dc.contributor.authorFernandez-Navarro, Pablo 
dc.contributor.authorCastaño-Vinyals, Gemma
dc.contributor.authorLlorca, Javier
dc.contributor.authorSalas, Dolores
dc.contributor.authorSalcedo-Bellido, Inmaculada
dc.contributor.authorAragones, Nuria 
dc.contributor.authorFernández-Tardón, Guillermo
dc.contributor.authorAlguacil, Juan
dc.contributor.authorGracia-Lavedan, Esther
dc.contributor.authorGarcia-Esquinas, Esther
dc.contributor.authorGómez-Acebo, Inés
dc.contributor.authorAmiano, Pilar
dc.contributor.authorRomaguera, Dora
dc.contributor.authorKogevinas, Manolis
dc.contributor.authorPollan-Santamaria, Marina 
dc.contributor.authorPerez-Gomez, Beatriz 
dc.date.accessioned2020-01-16T07:55:30Z
dc.date.available2020-01-16T07:55:30Z
dc.date.issued2018-12-20
dc.identifier.citationNutrients. 2018 Dec 20;11(1). pii: E18.es_ES
dc.identifier.issn2072-6643es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/8904
dc.description.abstractZinc is a key trace element in normal prostate cell metabolism, and is decreased in neoplastic cells. However, the association between dietary zinc and prostate cancer (PC) in epidemiologic studies is a conflicting one. Our aim was to explore this association in an MCC-Spain case-control study, considering tumor aggressiveness and extension, as well as genetic susceptibility to PC. 733 incident cases and 1228 population-based controls were included for this study. Dietary zinc was assessed using a food frequency questionnaire, and genetic susceptibility was assessed with a single nucleotide polymorphisms (SNP)-based polygenic risk score (PRS). The association between zinc intake and PC was evaluated with mixed logistic and multinomial regression models. They showed an increased risk of PC in those with higher intake of zinc (Odds Ratio (OR) tertile 3vs1: 1.39; 95% Confidence interval (CI):1.00⁻1.95). This association was mainly observed in low grade PC (Gleason = 6 RRR tertile 3vs1: 1.76; 95% CI:1.18⁻2.63) as well as in localized tumors (cT1-cT2a RRR tertile 3vs1: 1.40; 95% CI:1.00⁻1.95) and among those with higher PRS (OR tertile 3vs1: 1.50; 95% CI:0.89⁻2.53). In conclusion, a higher dietary zinc intake could increase the risk of low grade and localized tumors. Men with higher genetic susceptibility0020might also have a higher risk of PC associated with this nutrient intake.es_ES
dc.description.sponsorshipThe study was supported by the “Acción Transversal del Cáncer”, approved on the Spanish Ministry Council on the 11 October 2007, by the Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), by the Instituto de Salud Carlos III grants, co-funded by FEDER funds -a way to build Europe- PI08/1770, PI09/0773, PI12/00715, PI09/1903,PI09/2078; PI09/1662; PI11/01403; PI12/00150; PI12/00488; PI15/00914; PI17CIII_00034;by the Fundación Marqués de Valdecilla grant API 10/09, by the Consejería de Salud of the Junta de Andalucía grant 2009-S0143, by the Conselleria de Sanitat of the Generalitat Valenciana grant AP061/10, by the Regional Government of the Basque Country, by the Fundación Caja de Ahorros de Asturias, by the University of Oviedo and by the Spanish Ministry of Economy and Competitiveness Juan de la Cierva de Incorporación grant IJCI-2014-20900.es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectdietes_ES
dc.subjectdietary zinces_ES
dc.subjectgenetic susceptibilityes_ES
dc.subjectprostate canceres_ES
dc.subject.meshAged es_ES
dc.subject.meshCase-Control Studies es_ES
dc.subject.meshDiet es_ES
dc.subject.meshDiet Surveys es_ES
dc.subject.meshEnergy Intake es_ES
dc.subject.meshHumans es_ES
dc.subject.meshMale es_ES
dc.subject.meshMiddle Aged es_ES
dc.subject.meshOdds Ratio es_ES
dc.subject.meshProstatic Neoplasms es_ES
dc.subject.meshRisk Factors es_ES
dc.subject.meshSpain es_ES
dc.subject.meshZinc es_ES
dc.titleDietary Zinc and Risk of Prostate Cancer in Spain: MCC-Spain Studyes_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID30577563es_ES
dc.format.volume11es_ES
dc.format.number1es_ES
dc.format.page18es_ES
dc.identifier.doi10.3390/nu11010018es_ES
dc.contributor.funderInstituto de Salud Carlos III - ISCIIIes_ES
dc.contributor.funderEuropean Regional Development Fund (ERDF/FEDER)es_ES
dc.contributor.funderFundación Marqués de Valdecillaes_ES
dc.contributor.funderGobierno de Andalucíaes_ES
dc.contributor.funderGeneralitat Valencianaes_ES
dc.contributor.funderGobierno Vascoes_ES
dc.contributor.funderFundación Caja de Ahorros de Asturiases_ES
dc.contributor.funderUniversidad de Oviedoes_ES
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn2072-6643es_ES
dc.relation.publisherversionhttps://doi.org/10.3390/nu11010018es_ES
dc.identifier.journalNutrientses_ES
dc.repisalud.centroISCIII::Centro Nacional de Epidemologíaes_ES
dc.repisalud.centroISCIII::Escuela Nacional de Sanidades_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI08/1770es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI09/0773es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI12/00715es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI09/1903es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI09/2078es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI09/1662es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI11/01403es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI12/00150es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI12/00488es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI15/00914es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI17CIII_00034es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/API 10/09es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/2009-S0143es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/AP061/10es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/IJCI-2014-20900es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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