Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/8903
The Dietary Inflammatory Index and Chronic Lymphocytic Leukaemia in the MCC Spain Study
Flores, José Carlos | Gracia-Lavedan, Esther | Benavente, Yolanda | Amiano, Pilar | Romaguera, Dora | Costas, Laura | Robles, Claudia | Gonzalez-Barca, Eva | de la Banda, Esmeralda | Alonso, Esther | Aymerich, Marta | Campo, Elias | Dierssen-Sotos, Trinidad | Marcos-Gragera, Rafael | Rodríguez-Suárez, Marta María | Solans, Marta | Gimeno, Eva | Garcia Martin, Paloma | Aragones, Nuria ISCIII | Shivappa, Nitin | Hébert, James R | Pollan-Santamaria, Marina ISCIII | Kogevinas, Manolis | de Sanjose, Silvia | Castaño-Vinyals, Gemma | Casabonne, Delphine
Nutrients. 2019 Dec 23;12(1). pii: E48.
Chronic inflammation plays a role in the development of chronic lymphocytic leukaemia (CLL), and diet might modulate chronic inflammation. This study aims to evaluate the association between the dietary inflammatory index (DII®) and CLL. A total of 366 CLL cases and 1643 controls of the Spanish multicase-control (MCC) Spain study were included. The inflammatory potential of the diet was assessed using the energy-adjusted dietary inflammatory index (E-DII) based on 30 items from a validated semi-quantitative food frequency questionnaire. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using logistic regression models controlling for potential confounders. Overall, a modest, non-statistically significant, positive association was observed between CLL and E-DII scores (OR for a one-unit increase in E-DII: 1.05 (CI 95%: 0.99, 1.12), p-value = 0.09 and by tertiles: ORT2vsT1: 1.20 (CI 95%: 0.90, 1.59); OR T3vsT1: 1.21 (CI 95%: 0.90, 1.62), p trend = 0.21). These results were independent from disease severity (p-het: 0.70), time from diagnosis (p-het: 0.67) and CLL treatment received (p-het: 0.56). No interactions were detected. In conclusion, the consumption of a diet with high pro-inflammatory components was not significantly associated with CLL. Changes towards a more pro-inflammatory dietary pattern in younger generations not included here warrant future research.
MCC Spain study | cancer | case-control study | chronic lymphocytic leukaemia | dietary inflammatory index | nutrition
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