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dc.contributor.author | Jimenez-Sousa, Maria Angeles | |
dc.contributor.author | Fadrique, Alejandra | |
dc.contributor.author | Liu, Pilar | |
dc.contributor.author | Fernandez-Rodriguez, Amanda | |
dc.contributor.author | Lorenzo-López, Mario | |
dc.contributor.author | Gómez-Sánchez, Esther | |
dc.contributor.author | Gomez-Sanz, Alicia | |
dc.contributor.author | Heredia-Rodríguez, María | |
dc.contributor.author | Gómez-Pesquera, Estefanía | |
dc.contributor.author | Martinez, Isidoro | |
dc.contributor.author | Tamayo, Eduardo | |
dc.contributor.author | Resino, Salvador | |
dc.date.accessioned | 2020-01-15T12:51:30Z | |
dc.date.available | 2020-01-15T12:51:30Z | |
dc.date.issued | 2019-02-26 | |
dc.identifier.citation | J Clin Med. 2019 Feb 26;8(3). pii: E283. | es_ES |
dc.identifier.issn | 2077-0383 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/8895 | |
dc.description.abstract | BACKGROUND: In many immune-related diseases, inflammatory responses and several clinical outcomes are related to increased NF-κB activity. We aimed to evaluate whether SNPs related to the NF-κB signaling pathway are associated with higher susceptibility to infection, septic shock, and septic-shock-related death in European patients who underwent major surgery. METHODS: We performed a case-control study on 184 patients with septic shock and 212 with systemic inflammatory response syndrome, and a longitudinal substudy on septic shock patients. Thirty-three SNPs within genes belonging to or regulating the NF-κB signaling pathway were genotyped by Agena Bioscience's MassARRAY platform. RESULTS: No significant results were found for susceptibility to infection and septic shock in the multivariate analysis after adjusting for multiple comparisons. Regarding septic-shock-related death, patients with TNFAIP3 rs6920220 AA, TNIP1 rs73272842 AA, TNIP1 rs3792783 GG, and TNIP1 rs7708392 CC genotypes had the highest risk of septic-shock-related death in the first 28 and 90 days. Also, the MyD88 rs7744 GG genotype was associated with a higher risk of death during the first 90 days. Haplotype analysis shows us that patients with the TNIP1 GAG haplotype (composed of rs73272842, rs3792783, and rs7708392) had a lower risk of death in the first 28 days and the TNIP1 AGC haplotype was associated with a higher risk of death in the first 90 days. CONCLUSIONS: The SNPs in the genes TNFAIP3, TNIP1, and MyD88 were linked to the risk of septic-shock-related death in patients who underwent major surgery. | es_ES |
dc.description.sponsorship | This work has been supported by grants given by Instituto de Salud Carlos III (grant numbers PI15/01451 to ET), “Gerencia de Salud, Consejería de Sanidad, Junta de Castilla y Leon” [grant number GRS 463/A/10 and 773/A/13 to ET], and PFIZER [grant number CT25-ESP01-01 to SR]. A.F.-R. is supported by “Instituto de Salud Carlos III” [grant numbers CP14CIII/00010]. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | MyD88 | es_ES |
dc.subject | SNPs | es_ES |
dc.subject | TNFAIP3 | es_ES |
dc.subject | TNIP1 | es_ES |
dc.subject | Major surgery | es_ES |
dc.subject | Septic shock | es_ES |
dc.subject | Survival | es_ES |
dc.title | TNFAIP3, TNIP1, and MyD88 Polymorphisms Predict Septic-Shock-Related Death in Patients Who Underwent Major Surgery | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 30813592 | es_ES |
dc.format.volume | 8 | es_ES |
dc.format.number | 3 | es_ES |
dc.format.page | 283 | es_ES |
dc.identifier.doi | 10.3390/jcm8030283 | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.contributor.funder | Junta de Castilla y León (España) | |
dc.description.peerreviewed | Sí | es_ES |
dc.relation.publisherversion | https://doi.org/10.3390/jcm8030283 | es_ES |
dc.identifier.journal | Journal of clinical medicine | es_ES |
dc.repisalud.centro | ISCIII::Centro Nacional de Microbiología | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI15/01451 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/GRS 463/A/10 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/773/A/13 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/CT25-ESP01-01 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/CP14CIII/00010 | es_ES |
dc.rights.accessRights | open access | es_ES |