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dc.contributor.authorJimenez-Sousa, Maria Angeles 
dc.contributor.authorFadrique, Alejandra
dc.contributor.authorLiu, Pilar
dc.contributor.authorFernandez-Rodriguez, Amanda 
dc.contributor.authorLorenzo-López, Mario
dc.contributor.authorGómez-Sánchez, Esther
dc.contributor.authorGomez-Sanz, Alicia 
dc.contributor.authorHeredia-Rodríguez, María
dc.contributor.authorGómez-Pesquera, Estefanía
dc.contributor.authorMartinez, Isidoro 
dc.contributor.authorTamayo, Eduardo
dc.contributor.authorResino, Salvador 
dc.date.accessioned2020-01-15T12:51:30Z
dc.date.available2020-01-15T12:51:30Z
dc.date.issued2019-02-26
dc.identifier.citationJ Clin Med. 2019 Feb 26;8(3). pii: E283.es_ES
dc.identifier.issn2077-0383es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/8895
dc.description.abstractBACKGROUND: In many immune-related diseases, inflammatory responses and several clinical outcomes are related to increased NF-κB activity. We aimed to evaluate whether SNPs related to the NF-κB signaling pathway are associated with higher susceptibility to infection, septic shock, and septic-shock-related death in European patients who underwent major surgery. METHODS: We performed a case-control study on 184 patients with septic shock and 212 with systemic inflammatory response syndrome, and a longitudinal substudy on septic shock patients. Thirty-three SNPs within genes belonging to or regulating the NF-κB signaling pathway were genotyped by Agena Bioscience's MassARRAY platform. RESULTS: No significant results were found for susceptibility to infection and septic shock in the multivariate analysis after adjusting for multiple comparisons. Regarding septic-shock-related death, patients with TNFAIP3 rs6920220 AA, TNIP1 rs73272842 AA, TNIP1 rs3792783 GG, and TNIP1 rs7708392 CC genotypes had the highest risk of septic-shock-related death in the first 28 and 90 days. Also, the MyD88 rs7744 GG genotype was associated with a higher risk of death during the first 90 days. Haplotype analysis shows us that patients with the TNIP1 GAG haplotype (composed of rs73272842, rs3792783, and rs7708392) had a lower risk of death in the first 28 days and the TNIP1 AGC haplotype was associated with a higher risk of death in the first 90 days. CONCLUSIONS: The SNPs in the genes TNFAIP3, TNIP1, and MyD88 were linked to the risk of septic-shock-related death in patients who underwent major surgery.es_ES
dc.description.sponsorshipThis work has been supported by grants given by Instituto de Salud Carlos III (grant numbers PI15/01451 to ET), “Gerencia de Salud, Consejería de Sanidad, Junta de Castilla y Leon” [grant number GRS 463/A/10 and 773/A/13 to ET], and PFIZER [grant number CT25-ESP01-01 to SR]. A.F.-R. is supported by “Instituto de Salud Carlos III” [grant numbers CP14CIII/00010].es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectMyD88es_ES
dc.subjectSNPses_ES
dc.subjectTNFAIP3es_ES
dc.subjectTNIP1es_ES
dc.subjectmajor surgeryes_ES
dc.subjectseptic shockes_ES
dc.subjectsurvivales_ES
dc.titleTNFAIP3, TNIP1, and MyD88 Polymorphisms Predict Septic-Shock-Related Death in Patients Who Underwent Major Surgeryes_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID30813592es_ES
dc.format.volume8es_ES
dc.format.number3es_ES
dc.format.page283es_ES
dc.identifier.doi10.3390/jcm8030283es_ES
dc.contributor.funderInstituto de Salud Carlos III - ISCIII
dc.contributor.funderJunta de Castilla y León
dc.description.peerreviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.3390/jcm8030283es_ES
dc.identifier.journalJournal of clinical medicinees_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI15/01451es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/GRS 463/A/10es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/773/A/13es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/CT25-ESP01-01es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/CP14CIII/00010es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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