Show simple item record

dc.contributor.authorLopez-Huertas, Maria Rosa 
dc.contributor.authorPalladino, Claudia
dc.contributor.authorGarrido-Arquero, Marta 
dc.contributor.authorEsteban-Cartelle, Beatriz 
dc.contributor.authorSanchez-Carrillo, Marta 
dc.contributor.authorMartinez-Roman, Paula 
dc.contributor.authorMartín-Carbonero, Luz
dc.contributor.authorRyan, Pablo
dc.contributor.authorDomínguez-Domínguez, Lourdes
dc.contributor.authorDe Los Santos, Ignacio
dc.contributor.authorDe La Fuente Moral, Sara
dc.contributor.authorBenito, José Miguel
dc.contributor.authorRallón, Norma
dc.contributor.authorAlcamí, José 
dc.contributor.authorResino, Salvador 
dc.contributor.authorFernandez-Rodriguez, Amanda 
dc.contributor.authorCoiras, Mayte 
dc.contributor.authorBriz, Verónica 
dc.date.accessioned2020-01-15T12:48:58Z
dc.date.available2020-01-15T12:48:58Z
dc.date.issued2019-04-03
dc.identifier.citationSci Rep. 2019 Apr 3;9(1):5606.es_ES
dc.identifier.issn2045-2322es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/8888
dc.description.abstractIn HIV-1/HCV-coinfected patients, chronic HCV infection leads to an increased T-lymphocyte immune activation compared to HIV-monoinfected patients, thereby likely contributing to increase HIV-1 reservoir that is the major barrier for its eradication. Our objective was to evaluate the influence of HCV coinfection in HIV-1 viral reservoir size in resting (r) CD4+ T-cells (CD25-CD69-HLADR-). Multicenter cross-sectional study of 97 cART-treated HIV-1 patients, including 36 patients with HIV and HCV-chronic co-infection without anti-HCV treatment, 32 HIV patients with HCV spontaneous clearance and 29 HIV-monoinfected patients. rCD4+ T-cells were isolated and total DNA was extracted. HIV viral reservoir was measured by Alu-LTR qPCR. Differences between groups were calculated with a generalized linear model. Overall, 63.9% were men, median age of 41 years and Caucasian. Median CD4+ and CD8+ T-lymphocytes were 725 and 858 cells/mm3, respectively. CD4+ T nadir cells was 305 cells/mm3. Proviral HIV-1 DNA size was significantly increased in chronic HIV/HCV-coinfected compared to HIV-monoinfected patients (206.21 ± 47.38 vs. 87.34 ± 22.46, respectively; P = 0.009), as well as in spontaneously clarified HCV co-infected patients when compared to HIV-monoinfected individuals (136.20 ± 33.20; P = 0.009). HIV-1/HCV co-infected patients showed a larger HIV-1 reservoir size in comparison to HIV-monoinfected individuals. This increase could lead to a greater complexity in the elimination of HIV-1 reservoir in HIV-1/HCV-coinfected individuals, which should be considered in the current strategies for the elimination of HIV-1 reservoir.es_ES
dc.description.sponsorshipThe authors thank all the patients for their participation. Financial support was provided by the Instituto de Salud Carlos III to VB (PI15CIII/00031), by the Spanish Ministry of Economy and Competitiveness to MC (SAF2016–78480-R) and The SPANISH AIDS Research Network RD16CIII/0002/0001, RD16CIII/0002/0002 and RD16/0025/0013 - ISCIII – FEDER. MRLP is supported by ISCIII - Subdirección General de Evaluacion and European Funding for Regional Development (FEDER) (PIE 13/00040 and RD12/0017/0017 RETIC de SIDA). C.P. is supported by the Portuguese Fundação para a Ciência e Tecnologia (FCT) (grant number SFRH/BPD/77448/2011 is part of the EDCTP2 programme supported by the European Union). V.B., A.F.R. and N.R. are supported by the Miguel Servet programme from Fondo de Investigación Sanitaria (ISCIII) (grant number CP13/00098, CP14/CIII/00010 and CP14/00198, respectively).es_ES
dc.language.isoenges_ES
dc.publisherNature Researches_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleHCV-coinfection is related to an increased HIV-1 reservoir size in cART-treated HIV patients: a cross-sectional studyes_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID30944340es_ES
dc.format.volume9es_ES
dc.format.number1es_ES
dc.format.page5606es_ES
dc.identifier.doi10.1038/s41598-019-41788-9es_ES
dc.contributor.funderInstituto de Salud Carlos III - ISCIII
dc.contributor.funderMinisterio de Economía y Competitividad (España)
dc.contributor.funderRed Española de Investigación en SIDA
dc.contributor.funderEuropean Regional Development Fund (ERDF/FEDER)
dc.contributor.funderFondo de Investigaciones Sanitarias
dc.description.peerreviewedes_ES
dc.identifier.e-issn2045-2322es_ES
dc.relation.publisherversionhttps://doi.org/10.1038/s41598-019-41788-9es_ES
dc.identifier.journalScientific reportses_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI15CIII/00031es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2016–78480-Res_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/RD16CIII/0002/0001es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/RD16CIII/0002/0002es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/RD16/0025/0013es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PIE 13/00040es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/RD12/0017/0017 RETIC de SIDAes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SFRH/BPD/77448/2011es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/CP13/00098es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/CP14/CIII/00010es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/CP14/00198es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


Files in this item

Acceso Abierto
Thumbnail

This item appears in the following Collection(s)

Show simple item record

Atribución 4.0 Internacional
This item is licensed under a: Atribución 4.0 Internacional