Mostrar el registro sencillo del ítem

dc.contributor.authorIbáñez-Sanz, Gemma
dc.contributor.authorDíez-Villanueva, Anna
dc.contributor.authorRiera-Ponsati, Marina
dc.contributor.authorFernández-Villa, Tania
dc.contributor.authorFernandez-Navarro, Pablo L 
dc.contributor.authorBustamante, Mariona
dc.contributor.authorLlorca, Javier
dc.contributor.authorAmiano, Pilar
dc.contributor.authorAscunce, Nieves
dc.contributor.authorFernández-Tardón, Guillermo
dc.contributor.authorSalcedo Bellido, Inmaculada
dc.contributor.authorSalas, Dolores
dc.contributor.authorCapelo Álvarez, Rocío
dc.contributor.authorCrous-Bou, Marta
dc.contributor.authorOrtega-Valín, Luis
dc.contributor.authorPerez-Gomez, Beatriz 
dc.contributor.authorCastaño-Vinyals, Gemma
dc.contributor.authorPalazuelos, Camilo
dc.contributor.authorAltzibar, Jone M
dc.contributor.authorArdanaz, Eva
dc.contributor.authorTardón, Adonina
dc.contributor.authorJiménez Moleón, José Juan
dc.contributor.authorOlmos Juste, Valle
dc.contributor.authorAragones, Nuria 
dc.contributor.authorPollan-Santamaria, Marina 
dc.contributor.authorKogevinas, Manolis
dc.contributor.authorMoreno, Victor
dc.date.accessioned2019-12-12T13:13:21Z
dc.date.available2019-12-12T13:13:21Z
dc.date.issued2019-09-16
dc.identifier.citationSci Rep. 2019 Sep 16;9(1):13407.es_ES
dc.identifier.issn2045-2322es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/8832
dc.description.abstractDyslipidemia and statin use have been associated with colorectal cancer (CRC), but prospective studies have shown mixed results. We aimed to determine whether dyslipidemia is causally linked to CRC risk using a Mendelian randomization approach and to explore the association of statins with CRC. A case-control study was performed including 1336 CRC cases and 2744 controls (MCC-Spain). Subjects were administered an epidemiological questionnaire and were genotyped with an array which included polymorphisms associated with blood lipids levels, selected to avoid pleiotropy. Four genetic lipid scores specific for triglycerides (TG), high density lipoprotein cholesterol (HDL), low density lipoprotein cholesterol (LDL), or total cholesterol (TC) were created as the count of risk alleles. The genetic lipid scores were not associated with CRC. The ORs per 10 risk alleles, were for TG 0.91 (95%CI: 0.72-1.16, p = 0.44), for HDL 1.14 (95%CI: 0.95-1.37, p = 0.16), for LDL 0.97 (95%CI: 0.81-1.16, p = 0.73), and for TC 0.98 (95%CI: 0.84-1.17, p = 0.88). The LDL and TC genetic risk scores were associated with statin use, but not the HDL or TG. Statin use, overall, was a non-significant protective factor for CRC (OR 0.84; 95%CI: 0.70-1.01, p = 0.060), but lipophilic statins were associated with a CRC risk reduction (OR 0.78; 95%CI 0.66-0.96, p = 0.018). Using the Mendelian randomization approach, our study does not support the hypothesis that lipid levels are associated with the risk of CRC. This study does not rule out, however, a possible protective effect of statins in CRC by a mechanism unrelated to lipid levels.es_ES
dc.description.sponsorshipThis work was supported by the ‘Acción Transversal del Cancer’, approved by the Spanish Ministry Council on the 11th October 2007, by the Instituto de Salud Carlos III, co-founded by FEDER funds –‘a way to build Europe’ [grants PI08/1770, PI08/0533, PI08/1359, PI09/00773, PI09/01286, PI09/01903, PI09/02078, PI09/01662, PI11/01403, PI11/01889, PI11/00226, PI11/01810, PI11/02213, PI12/00488, PI12/00265, PI12/01270, PI12/00715, PI12/00150, PI14/01219, PI14/00613, PI17/00092 and PI15/00069]. Support was also provided by the Fundación Marqués de Valdecilla (grant API 10/09]; the Junta de Castilla y León [grant LE22A10-2]; the Consejería de Salud of the Junta de Andalucía [2009-S0143]; the Conselleria de Sanitat of the Generalitat Valenciana [grant AP 061/10]; the Recercaixa [grant 2010ACUP 00310]; the Regional Government of the Basque Country; the Consejería de Sanidad de la Región de Murcia; European Commission grants FOOD-CT-2006-036224-HIWATE; the Spanish Association Against Cancer (AECC) Scientific Foundation; the Catalan Government DURSI [grants 2017SGR723 and 2014SGR850]; the Fundación Caja de Ahorros de Asturias; the University of Oviedo; Societat Catalana de Digestologia; and COST action CA17118 Transcoloncan. ISGlobal and IDIBELL are members of the CERCA Programme, Generalitat de Catalunya.es_ES
dc.language.isoenges_ES
dc.publisherNature Publishing Group es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleMendelian randomization analysis rules out disylipidaemia as colorectal cancer causees_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID31527690es_ES
dc.format.volume9es_ES
dc.format.number1es_ES
dc.format.page13407es_ES
dc.identifier.doi10.1038/s41598-019-49880-wes_ES
dc.contributor.funderInstituto de Salud Carlos III 
dc.contributor.funderFundación Marqués de Valdecilla 
dc.contributor.funderJunta de Castilla y León (España) 
dc.contributor.funderRegional Government of Andalusia (España) 
dc.contributor.funderGeneralitat Valenciana (España) 
dc.contributor.funderFundación La Caixa 
dc.contributor.funderBasque Government (España) 
dc.contributor.funderGobierno de la Región de Murcia (España) 
dc.contributor.funderUnión Europea. Comisión Europea 
dc.contributor.funderFundación Vencer el Cáncer 
dc.contributor.funderGovernment of Catalonia (España) 
dc.contributor.funderFundación Caja de Ahorros de Asturias 
dc.contributor.funderUniversity of Oviedo (España) 
dc.contributor.funderSociedad Catalana de Digestología 
dc.description.peerreviewedes_ES
dc.identifier.e-issn2045-2322es_ES
dc.relation.publisherversionhttps://doi.org/10.1038/s41598-019-49880-wes_ES
dc.identifier.journalScientific reportses_ES
dc.repisalud.centroISCIII::Centro Nacional de Epidemiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI08/1770es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI08/0533es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI08/1359es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI09/00773es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI09/01286es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI09/01903es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI09/02078es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI09/01662es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI11/01403es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI11/01889es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI11/00226es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI11/01810es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI11/02213es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI12/00488es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI12/00265es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI12/01270es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI12/00715es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI12/00150es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI14/01219es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI14/00613es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI17/00092es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI15/00069es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/API 10/09es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/LE22A10-2es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/2009-S0143es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/AP 061/10es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/2010ACUP 00310es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/FOOD-CT-2006-036224-HIWATEes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/2017SGR723es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/2014SGR850es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/COST action CA17118es_ES
dc.rights.accessRightsopen accesses_ES


Ficheros en el ítem

Acceso Abierto
Thumbnail

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

Atribución 4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Atribución 4.0 Internacional