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dc.contributor.authorFradejas, Isabel
dc.contributor.authorRubio Muñoz, Jose Miguel 
dc.contributor.authorMartín-Díaz, Ariadna
dc.contributor.authorHerrero-Martínez, Juan María
dc.contributor.authorRuiz-Giardin, José Manuel
dc.contributor.authorRojo-Marcos, Gerardo
dc.contributor.authorVelasco, María
dc.contributor.authorCalderón-Moreno, María
dc.contributor.authorAzcona-Gutiérrez, José Manuel
dc.contributor.authorMerino, Francisco Jesús
dc.contributor.authorOlmo, Belén Andrés
dc.contributor.authorEspinosa, María
dc.contributor.authorCuadrado, María
dc.contributor.authorGonzález-Monte, Esther
dc.contributor.authorJaqueti, Jerónimo
dc.contributor.authorCuadros, Juan
dc.contributor.authorCampelo, Carolina
dc.contributor.authorDelgado-Iribarren, Alberto
dc.contributor.authorMartín-Rabadán, Pablo
dc.contributor.authorGarcía-García, Concepción
dc.contributor.authorMartín-Laso, María Ángeles
dc.contributor.authorValle-Borrego, Beatriz
dc.contributor.authorGarcía, María Coral
dc.contributor.authorLizasoaín, Manuel
dc.contributor.authorPérez-Ayala, Ana
dc.date.accessioned2019-12-05T12:12:57Z
dc.date.available2019-12-05T12:12:57Z
dc.date.issued2019-07-17
dc.identifier.citationMalar J. 2019 Jul 17;18(1):242.es_ES
dc.identifier.issn1475-2875es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/8752
dc.description.abstractBACKGROUND: The importance of submicroscopic malaria infections in high-transmission areas could contribute to maintain the parasite cycle. Regarding non-endemic areas, its importance remains barely understood because parasitaemia in these afebrile patients is usually below the detection limits for microscopy, hence molecular techniques are often needed for its diagnosis. In addition to this, the lack of standardized protocols for the screening of submicroscopic malaria in immigrants from endemic areas may underestimate the infection with Plasmodium spp. The aim of this study was to assess the prevalence of submicroscopic malaria in afebrile immigrants living in a non-endemic area. METHODS: A prospective, observational, multicentre study was conducted. Afebrile immigrants were included, microscopic observation of Giemsa-stained thin and thick blood smears, and two different molecular techniques detecting Plasmodium spp. were performed. Patients with submicroscopic malaria were defined as patients with negative blood smears and detection of DNA of Plasmodium spp. with one or both molecular techniques. Demographic, clinical, analytical and microbiological features were recorded and univariate analysis by subgroups was carried out with STATA v15. RESULTS: A total of 244 afebrile immigrants were included in the study. Of them, 14 had a submicroscopic malaria infection, yielding a prevalence of 5.7% (95% confidence interval 3.45-9.40). In 71.4% of the positive PCR/negative microscopy cases, Plasmodium falciparum alone was the main detected species (10 out of the 14 patients) and in 4 cases (28.6%) Plasmodium vivax or Plasmodium ovale were detected. One patient had a mixed infection including three different species. CONCLUSIONS: The prevalence of submicroscopic malaria in afebrile immigrants was similar to that previously described in Spain. Plasmodium vivax and P. ovale were detected in almost a third of the submicroscopic infections. Screening protocols for afebrile immigrants with molecular techniques could be useful for a proper management of these patients.es_ES
dc.description.sponsorshipThis work was funded by projects PI14/01671, PI17/01791 and PI14CIII/00014, from the Instituto de Salud Carlos III (Ministry of Economy, Industry and Competitiveness) and cofounded by the European Regional Development Fund, and approved by the Ethics Committee of our Institution. There was no funding from the PCR manufacturers; they did not play any role in data analysis or in the reporting of the results.es_ES
dc.language.isoenges_ES
dc.publisherBioMed Central (BMC) es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectAfebrile malariaes_ES
dc.subjectImmigrantes_ES
dc.subjectPlasmodiumes_ES
dc.subjectSubmicroscopic parasitaemiaes_ES
dc.subjectTropical medicinees_ES
dc.subject.meshAdult es_ES
dc.subject.meshAsymptomatic Diseases es_ES
dc.subject.meshCoinfection es_ES
dc.subject.meshEmigrants and Immigrants es_ES
dc.subject.meshFemale es_ES
dc.subject.meshHumans es_ES
dc.subject.meshMalaria es_ES
dc.subject.meshMalaria, Falciparum es_ES
dc.subject.meshMalaria, Vivax es_ES
dc.subject.meshMale es_ES
dc.subject.meshMicroscopy es_ES
dc.subject.meshMiddle Aged es_ES
dc.subject.meshPlasmodium falciparum es_ES
dc.subject.meshPlasmodium ovale es_ES
dc.subject.meshPlasmodium vivax es_ES
dc.subject.meshPrevalence es_ES
dc.subject.meshSpain es_ES
dc.titlePrevalence of submicroscopic malaria infection in immigrants living in Spaines_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID31315624es_ES
dc.format.volume18es_ES
dc.format.number1es_ES
dc.format.page242es_ES
dc.identifier.doi10.1186/s12936-019-2870-3es_ES
dc.contributor.funderInstituto de Salud Carlos III 
dc.contributor.funderUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) 
dc.description.peerreviewedes_ES
dc.identifier.e-issn1475-2875es_ES
dc.relation.publisherversionhttps://doi.org/10.1186/s12936-019-2870-3es_ES
dc.identifier.journalMalaria journales_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI14/01671es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI17/01791es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI14CIII/00014es_ES
dc.rights.accessRightsopen accesses_ES


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Atribución 4.0 Internacional
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